Methiothepin mesylate causes apoptosis of human prostate cancer cells by mediating oxidative stress and mitochondrial dysfunction.
Apoptosis
Methiothepin mesylate
Mitochondria
Oxidative stress
Prostate cancer
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
03
12
2019
revised:
30
01
2020
accepted:
31
01
2020
pubmed:
9
2
2020
medline:
22
6
2021
entrez:
9
2
2020
Statut:
ppublish
Résumé
Prostate cancer is difficult to treat if it metastasizes to other organs. The development of prostate cancer independent of androgen is closely related to the action of neuroendocrine products. Serotonin promotes cell growth in various cancers, and antagonists for serotonin receptors are known to inhibit proliferation and induce cell death in various carcinomas. However, little is known about how antagonists for serotonin receptor function in prostate cancer. We verified apoptotic cell death in prostate cancer cell lines after treatment with methiothepin mesylate (MET), an antagonist for serotonin receptor 5-HT
Identifiants
pubmed: 32035100
pii: S0891-5849(19)32442-6
doi: 10.1016/j.freeradbiomed.2020.01.187
pii:
doi:
Substances chimiques
Mesylates
0
Methiothepin
55D94103HL
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12-22Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have declared no conflict of interest.