Mechanistic understanding of β-cryptoxanthin and lycopene in cancer prevention in animal models.
Cancer prevention
Carotenoids
Lycopene
Molecular mechanisms
β-Cryptoxanthin
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
04
12
2019
revised:
26
01
2020
accepted:
28
01
2020
pubmed:
9
2
2020
medline:
1
1
2021
entrez:
9
2
2020
Statut:
ppublish
Résumé
To better understand the potential function of carotenoids in the chemoprevention of cancers, mechanistic understanding of carotenoid action on genetic and epigenetic signaling pathways is critically needed for human studies. The use of appropriate animal models is the most justifiable approach to resolve mechanistic issues regarding protective effects of carotenoids at specific organs and tissue sites. While the initial impetus for studying the benefits of carotenoids in cancer prevention was their antioxidant capacity and pro-vitamin A activity, significant advances have been made in the understanding of the action of carotenoids with regards to other mechanisms. This review will focus on two common carotenoids, provitamin A carotenoid β-cryptoxanthin and non-provitamin A carotenoid lycopene, as promising chemopreventive agents or chemotherapeutic compounds against cancer development and progression. We reviewed animal studies demonstrating that β-cryptoxanthin and lycopene effectively prevent the development or progression of various cancers and the potential mechanisms involved. We highlight recent research that the biological functions of β-cryptoxanthin and lycopene are mediated, partially via their oxidative metabolites, through their effects on key molecular targeting events, such as NF-κB signaling pathway, RAR/PPARs signaling, SIRT1 signaling pathway, and p53 tumor suppressor pathways. The molecular targets by β-cryptoxanthin and lycopene, offer new opportunities to further our understanding of common and distinct mechanisms that involve carotenoids in cancer prevention. This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro.
Identifiants
pubmed: 32035228
pii: S1388-1981(20)30044-5
doi: 10.1016/j.bbalip.2020.158652
pmc: PMC7415495
mid: NIHMS1556866
pii:
doi:
Substances chimiques
Antioxidants
0
Beta-Cryptoxanthin
0
NF-kappa B
0
Tumor Suppressor Protein p53
0
Sirtuin 1
EC 3.5.1.-
Lycopene
SB0N2N0WV6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
158652Subventions
Organisme : NCI NIH HHS
ID : R01 CA104932
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA176256
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest.
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