Riluzole: a therapeutic strategy in Alzheimer's disease by targeting the WNT/β-catenin pathway.
Alzheimer's disease
Riluzole
WNT pathway
glutamate
oxidative stress
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
08 02 2020
08 02 2020
Historique:
received:
11
12
2019
accepted:
27
01
2020
pubmed:
9
2
2020
medline:
23
1
2021
entrez:
9
2
2020
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is a neurodegenerative disease, where the etiology remains unclear. AD is characterized by amyloid-(Aβ) protein aggregation and neurofibrillary plaques deposits. Oxidative stress and chronic inflammation have been suggested as causes of AD. Glutamatergic pathway dysregulation is also mainly associated with AD process. In AD, the canonical WNT/β-catenin pathway is downregulated. Downregulation of WNT/β-catenin, by activation of GSK-3β-induced Aβ, and inactivation of PI3K/Akt pathway involve oxidative stress in AD. The downregulation of the WNT/β-catenin pathway decreases the activity of EAAT2, the glutamate receptors, and leads to neuronal death. In AD, oxidative stress, neuroinflammation and glutamatergic pathway operate in a vicious circle driven by the dysregulation of the WNT/β-catenin pathway. Riluzole is a glutamate modulator and used as treatment in amyotrophic lateral sclerosis. Recent findings have highlighted its use in AD and its potential increase power on the WNT pathway. Nevertheless, the mechanism by which Riluzole can operate in AD remains unclear and should be better determine. The focus of our review is to highlight the potential action of Riluzole in AD by targeting the canonical WNT/β-catenin pathway to modulate glutamatergic pathway, oxidative stress and neuroinflammation.
Identifiants
pubmed: 32035419
doi: 10.18632/aging.102830
pii: 102830
pmc: PMC7041777
doi:
Substances chimiques
Neuroprotective Agents
0
Wnt Proteins
0
beta Catenin
0
Riluzole
7LJ087RS6F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3095-3113Références
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