The cerebellum and epilepsy.
Channelrhodopsin
Deep brain stimulation
Fastigial nucleus
Halorhodopsin
Temporal lobe epilepsy
Thalamus
Journal
Epilepsy & behavior : E&B
ISSN: 1525-5069
Titre abrégé: Epilepsy Behav
Pays: United States
ID NLM: 100892858
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
29
10
2019
revised:
09
01
2020
accepted:
09
01
2020
pubmed:
10
2
2020
medline:
12
8
2021
entrez:
10
2
2020
Statut:
ppublish
Résumé
Epilepsy is the fourth most common neurological disorder, but current treatment options provide limited efficacy and carry the potential for problematic adverse effects. There is an immense need to develop new therapeutic interventions in epilepsy, and targeting areas outside the seizure focus for neuromodulation has shown therapeutic value. While not traditionally associated with epilepsy, anatomical, clinical, and electrophysiological studies suggest the cerebellum can play a role in seizure networks, and importantly, may be a potential therapeutic target for seizure control. However, previous interventions targeting the cerebellum in both preclinical and clinical studies have produced mixed effects on seizures. These inconsistent results may be due in part to the lack of specificity inherent with open-loop electrical stimulation interventions. More recent studies, using more targeted closed-loop optogenetic approaches, suggest the possibility of robust seizure inhibition via cerebellar modulation for a range of seizure types. Therefore, while the mechanisms of cerebellar inhibition of seizures have yet to be fully elucidated, the cerebellum should be thoroughly revisited as a potential target for therapeutic intervention in epilepsy. This article is part of the Special Issue "NEWroscience 2018.
Identifiants
pubmed: 32035793
pii: S1525-5050(19)31166-7
doi: 10.1016/j.yebeh.2020.106909
pmc: PMC7415499
mid: NIHMS1569201
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
106909Subventions
Organisme : NINDS NIH HHS
ID : R01 NS104071
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS112518
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no competing financial interests.
Références
Neurol India. 2019 Jan-Feb;67(1):169-172
pubmed: 30860118
Epilepsia. 1998 Jun;39(6):640-50
pubmed: 9637607
J Neurochem. 1977 Jul;29(1):43-51
pubmed: 196043
Electroencephalogr Clin Neurophysiol. 1967 Nov;23(5):456-62
pubmed: 4168976
J Physiol. 1957 Jan 23;135(1):73-92
pubmed: 13398967
Front Neuroinform. 2019 Mar 06;12:101
pubmed: 30894811
Bol Estud Med Biol. 1974 Oct-1975 Apr;28(8-10):285-301
pubmed: 4220106
Exp Neurol. 1962 Jul;6:48-69
pubmed: 13892435
Ann Neurol. 2015 Jun;77(6):1027-49
pubmed: 25762286
Electroencephalogr Clin Neurophysiol. 1974 Aug;37(2):123-32
pubmed: 4135018
Epilepsia Open. 2019 Jan 29;4(1):187-192
pubmed: 30868130
Neurobiol Dis. 2018 Mar;111:80-90
pubmed: 29274430
J Neurochem. 1979 Mar;32(3):743-53
pubmed: 219146
Brain Imaging Behav. 2020 Jun;14(3):762-771
pubmed: 30617780
PLoS Comput Biol. 2018 Dec 6;14(12):e1006606
pubmed: 30521519
Front Neurol. 2019 Jun 06;10:601
pubmed: 31244761
Neuron. 2018 Aug 8;99(3):564-575.e2
pubmed: 30017394
Neurology. 2015 Feb 24;84(8):810-7
pubmed: 25616485
Cerebellum. 2012 Jun;11(2):420-1
pubmed: 22278661
Clin Nucl Med. 1997 Mar;22(3):194-5
pubmed: 9067682
Electroencephalogr Clin Neurophysiol. 1978 Mar;44(3):373-9
pubmed: 76543
Int J Neural Syst. 2009 Jun;19(3):173-96
pubmed: 19575507
Neuroscience. 2007 Nov 23;149(4):834-44
pubmed: 17936513
Epilepsia. 2001 Sep;42(9):1204-7
pubmed: 11580771
Neurosurg Focus. 2010 Aug;29(2):E8
pubmed: 20672925
Cell Rep. 2018 May 29;23(9):2690-2704
pubmed: 29847799
Exp Neurol. 1976 Feb;50(2):505-14
pubmed: 1248564
Front Neural Circuits. 2013 Mar 13;7:35
pubmed: 23493515
Cerebellum. 2016 Aug;15(4):535-41
pubmed: 26208704
Epilepsia. 1975 Jun;16(2):257-67
pubmed: 1149712
J Anat. 1994 Apr;184 ( Pt 2):419-23
pubmed: 7516932
Epilepsia. 2016 Apr;57(4):621-9
pubmed: 26865066
Appl Neurophysiol. 1975;38(2):81-90
pubmed: 769688
J Neurosurg. 1978 Jan;48(1):69-84
pubmed: 619026
Acta Physiol Acad Sci Hung. 1964;24:321-33
pubmed: 14159891
Epilepsia. 2000 Oct;41(10):1315-20
pubmed: 11051128
Epilepsia. 2014 Jan;55(1):137-45
pubmed: 24313597
J Nucl Med. 1996 Mar;37(3):426-9
pubmed: 8772637
Cerebellum. 2019 Dec;18(6):1064-1097
pubmed: 31165428
Acta Neuropathol. 1984;62(4):332-9
pubmed: 6730909
J Neurosci. 2014 Dec 10;34(50):16671-87
pubmed: 25505320
Front Syst Neurosci. 2014 Jun 17;8:113
pubmed: 24987338
Can J Neurol Sci. 1978 Nov;5(4):405-11
pubmed: 743650
J Comp Neurol. 1978 Apr 1;178(3):495-517
pubmed: 19626723
J Comp Neurol. 1992 Dec 22;326(4):549-60
pubmed: 1484123
Neurosci Lett. 2019 Jan 1;688:62-75
pubmed: 29997061
Exp Neurol. 1977 Jul;56(1):189-99
pubmed: 862690
Epilepsia. 1972 Jul;13(3):401-8
pubmed: 4626569
Front Comput Neurosci. 2017 Apr 26;11:31
pubmed: 28491031
Histochem Cell Biol. 2008 Oct;130(4):601-15
pubmed: 18677503
J Comp Neurol. 1996 Nov 25;375(4):618-40
pubmed: 8930789
J Neurosurg. 1978 Mar;48(3):407-16
pubmed: 344840
Neuron. 2017 Jan 4;93(1):194-210
pubmed: 27989462
Epilepsia. 2013 Oct;54(10):1823-33
pubmed: 24032641
Nat Protoc. 2013 Aug;8(8):1475-1493
pubmed: 23845961
Electroencephalogr Clin Neurophysiol. 1959 Aug;11(3):439-46
pubmed: 13663818
Epilepsy Curr. 2016 May-Jun;16(3):170-1
pubmed: 27330445
Brain Res. 1980 Oct 27;200(1):93-103
pubmed: 6251946
Electroencephalogr Clin Neurophysiol. 1962 Jun;14:383-98
pubmed: 13887605
Epilepsia. 2000 Nov;41(11):1456-62
pubmed: 11077460
Front Cell Neurosci. 2018 Jun 14;12:151
pubmed: 29962936
Epilepsia. 1969 Sep;10(3):351-62
pubmed: 5256908
Brain. 2009 Apr;132(Pt 4):999-1012
pubmed: 19339252
J Neurosci. 2009 Aug 12;29(32):10104-10
pubmed: 19675244
Elife. 2015 May 12;4:
pubmed: 25965178
Electroencephalogr Clin Neurophysiol. 1968 Oct;25(4):359-71
pubmed: 4176541
Neuron. 2016 Feb 3;89(3):645-57
pubmed: 26844836
J Comput Neurosci. 1998 Mar;5(1):17-33
pubmed: 9540047
eNeuro. 2014 Dec;1(1):
pubmed: 25599088
JAMA Neurol. 2015 Jul;72(7):823-9
pubmed: 25961887
Trends Cogn Sci. 2017 May;21(5):313-332
pubmed: 28385461
J Neurol. 2013 Jun;260(6):1601-10
pubmed: 23355177
Epilepsia. 2005 Jul;46(7):1071-81
pubmed: 16026559
Clin Neuropathol. 1985 Nov-Dec;4(6):238-45
pubmed: 4075636
Epilepsy Res. 2016 Feb;120:98-103
pubmed: 26808205
J Nucl Med. 2001 Jun;42(6):853-8
pubmed: 11390547
Neurol Sci. 2016 Nov;37(11):1773-1778
pubmed: 27401807
Cerebellum. 2006;5(1):7-14
pubmed: 16527758
J Neurosurg. 2002 Jul;97(1):190-6
pubmed: 12134911
Neurosurg Focus. 2018 Aug;45(2):E13
pubmed: 30064319
Brain Res. 1977 Jan 1;119(1):21-41
pubmed: 830382
Epilepsia. 1978 Oct;19(5):493-504
pubmed: 729536
Epilepsy Behav. 2012 Oct;25(2):266-76
pubmed: 23041175
Neuron. 2015 Apr 22;86(2):529-40
pubmed: 25843404
Electroencephalogr Clin Neurophysiol. 1982 May;53(5):549-58
pubmed: 6177499
Epilepsy Res. 1993 Sep;16(1):1-9
pubmed: 8243435
Epilepsy Res. 2000 Aug;41(1):63-73
pubmed: 10924869
Neurol Neurochir Pol. 1981 Sep-Dec;15(5-6):605-9
pubmed: 6979000
J Neurochem. 1971 Jul;18(7):1197-205
pubmed: 5118877
Epilepsia. 2019 Apr;60(4):718-729
pubmed: 30868560
Int J Neurol. 1970;7(2):126-40
pubmed: 5499513
Electroencephalogr Clin Neurophysiol. 1979 Feb;46(2):189-96
pubmed: 86426
Ann Neurol. 1977 Mar;1(3):287-9
pubmed: 407835
J Clin Neurophysiol. 2015 Jun;32(3):194-206
pubmed: 26035672
Nat Rev Neurosci. 2006 Jul;7(7):511-22
pubmed: 16791141
Anat Rec (Hoboken). 2014 Jul;297(7):1306-15
pubmed: 24719368
Front Neural Circuits. 2018 Feb 07;12:6
pubmed: 29467628
Nat Neurosci. 2015 Mar;18(3):331-8
pubmed: 25710834
Can J Neurol Sci. 1987 Aug;14(3):306-8
pubmed: 3664373
Adv Neurol. 1999;79:991-9
pubmed: 10514881
Nat Commun. 2013;4:1376
pubmed: 23340416
J Comp Neurol. 1998 Mar 9;392(2):164-78
pubmed: 9512267
Trends Neurosci. 2017 May;40(5):309-323
pubmed: 28431742
Electroencephalogr Clin Neurophysiol. 1978 Feb;44(2):232-5
pubmed: 75096
Elife. 2019 Jun 17;8:
pubmed: 31205000
Brain. 1997 May;120 ( Pt 5):855-64
pubmed: 9183255
Cell Rep. 2019 May 21;27(8):2328-2334.e3
pubmed: 31116979
Electroencephalogr Clin Neurophysiol. 1974 Oct;37(4):355-65
pubmed: 4136705
Cerebellum. 2016 Apr;15(2):93-103
pubmed: 26112422
J Neurol Sci. 1991 Jun;103(2):127-35
pubmed: 1715386
Cerebellum. 2018 Dec;17(6):735-746
pubmed: 29982917
Clin Neurol Neurosurg. 2004 Sep;106(4):318-29
pubmed: 15297008
Neurology. 1978 Jul;28(7):654-60
pubmed: 566865
Appl Neurophysiol. 1983;46(1-4):57-61
pubmed: 6608318
Front Neural Circuits. 2014 Jan 28;7:96
pubmed: 24478634
Epilepsia. 1979 Jun;20(3):223-34
pubmed: 109292
Electroencephalogr Clin Neurophysiol. 1975 Apr;38(4):423-6
pubmed: 46822
J Neurosci. 1997 Jun 15;17(12):4517-26
pubmed: 9169512
Ann Neurol. 1986 Dec;20(6):737-40
pubmed: 3813502
Epilepsia. 1975 Sep;16(3):521-33
pubmed: 810347
Neurology. 1994 Jul;44(7):1332-3
pubmed: 8035941
Front Neural Circuits. 2019 Aug 09;13:51
pubmed: 31447652
J Neurosurg Pediatr. 2013 Sep;12(3):288-92
pubmed: 23808728
Trends Neurosci. 2015 Dec;38(12):787-799
pubmed: 26602765
Nature. 2015 Aug 6;524(7563):88-92
pubmed: 26131933
Epilepsia. 1955 Nov;4:19-28
pubmed: 13305547
Electroencephalogr Clin Neurophysiol. 1974 Feb;36(2):141-54
pubmed: 4129626
Neuroscience. 2010 Feb 17;165(4):1538-45
pubmed: 19945512
J Neurosci. 2013 Mar 20;33(12):5162-74
pubmed: 23516282
Exp Neurol. 1975 Nov;49(2):622-7
pubmed: 1193207
J Neurosci. 2014 Jan 22;34(4):1105-14
pubmed: 24453303
Front Syst Neurosci. 2015 Dec 22;9:177
pubmed: 26732845
J Neurosci. 2000 Apr 15;20(8):3006-16
pubmed: 10751453
Front Cell Neurosci. 2017 Oct 31;11:346
pubmed: 29163057
Seizure. 2018 Jan;54:51-57
pubmed: 29268230
Lancet. 1973 Jan 27;1(7796):206
pubmed: 4118825
Arch Neurol. 1976 Aug;33(8):536-42
pubmed: 942310
Clin Radiol. 2006 Nov;61(11):983-6
pubmed: 17018313
Epilepsia. 1979 Aug;20(4):447-54
pubmed: 477635
Ann Neurol. 1996 Jul;40(1):91-8
pubmed: 8687198
J Neurosurg. 1977 May;46(5):648-53
pubmed: 403255
Nat Neurosci. 2013 Jan;16(1):64-70
pubmed: 23143518
Cerebellum. 2013 Apr;12(2):199-204
pubmed: 22961557
Brain Res Bull. 1977 Sep-Oct;2(5):317-21
pubmed: 922510
Epilepsia. 1975 Jun;16(2):235-43
pubmed: 1097240
Acta Neurochir (Wien). 1976;(23 Suppl):257-62
pubmed: 1087103
Epilepsia. 1979 Jun;20(3):235-45
pubmed: 312731
Tremor Other Hyperkinet Mov (N Y). 2016 Jun 23;6:376
pubmed: 27375960
Epilepsy Res. 2013 Jul;105(1-2):245-9
pubmed: 23375885
J Neurol Neurosurg Psychiatry. 1984 Aug;47(8):769-74
pubmed: 6381652
Neurosci Behav Physiol. 2004 Oct;34(8):797-802
pubmed: 15587808
Biol Psychiatry. 1980 Aug;15(4):541-56
pubmed: 6772242
Stereotact Funct Neurosurg. 1992;58(1-4):200-8
pubmed: 1439341
Front Neurol. 2018 Dec 11;9:1079
pubmed: 30619039
Lancet Neurol. 2018 Dec;17(12):1098-1108
pubmed: 30366868
Neurology. 2015 Mar 10;84(10):1017-25
pubmed: 25663221
Science. 2011 Oct 21;334(6054):385-9
pubmed: 22021859
Exp Neurol. 1974 Nov;45(2):268-87
pubmed: 4422320
Annu Rev Neurosci. 2009;32:413-34
pubmed: 19555291
Neuroimage. 2018 Jun;173:370-383
pubmed: 29496611
J Neurosci. 2015 Nov 25;35(47):15635-48
pubmed: 26609157
Nat Commun. 2019 May 21;10(1):2251
pubmed: 31113954
J Physiol. 2020 Jan;598(1):171-187
pubmed: 31682010
Neuropharmacology. 2020 May 15;168:107751
pubmed: 31494141
Epilepsia. 2010 May;51(5):899-908
pubmed: 20331461
J Neurosci. 2011 Mar 16;31(11):4311-26
pubmed: 21411672
Neurobiol Dis. 2016 Mar;87:102-15
pubmed: 26721319