Evaluation of the bioequivalence and food effect on the bioavailability of CC-486 (oral azacitidine) tablets in adult patients with cancer.

Bioequivalence CC-486 Oral azacitidine Pharmacokinetics

Journal

Cancer chemotherapy and pharmacology
ISSN: 1432-0843
Titre abrégé: Cancer Chemother Pharmacol
Pays: Germany
ID NLM: 7806519

Informations de publication

Date de publication:
03 2020
Historique:
received: 28 09 2019
accepted: 22 01 2020
pubmed: 10 2 2020
medline: 10 2 2020
entrez: 10 2 2020
Statut: ppublish

Résumé

CC-486 is an oral formulation of azacitidine that allows for extended dosing schedules to prolong azacitidine exposure to malignant cells and maximize clinical activity. CC-486 300 mg daily, administered for 14 or 21 days of 28-day treatment cycles, is currently under investigation in two ongoing phase III trials. The 300-mg daily dose in these studies is administered as two 150-mg tablets (Formulation A). We evaluated the bioequivalence of one 300-mg CC-486 tablet (Formulation B) with Formulation A and food effect on Formulation B, in adult patients with cancer in a 2-stage crossover design study. The ratios of the geometric means of the maximum azacitidine plasma concentration (C The single 300-mg CC-486 tablet was bioequivalent to two 150-mg tablets, which have shown to be efficacious and generally well-tolerated in clinical trials, and can be taken with or without food.

Identifiants

pubmed: 32036412
doi: 10.1007/s00280-020-04037-9
pii: 10.1007/s00280-020-04037-9
pmc: PMC7036073
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

621-626

Subventions

Organisme : NCI NIH HHS
ID : R01 CA224917
Pays : United States

Commentaires et corrections

Type : ErratumIn

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Auteurs

Hani M Babiker (HM)

University of Arizona Comprehensive Cancer Center, Tucson, AZ, USA. hanibabiker@email.arizona.edu.

Mohammed Milhem (M)

University of Iowa Hospital, Iowa City, IA, USA.

Joseph Aisner (J)

Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.

William Edenfield (W)

Greenville Health System, Greenville, SC, USA.

Dale Shepard (D)

Cleveland Clinic, Cleveland, OH, USA.

Michael Savona (M)

Vanderbilt University Medical Center, Nashville, TN, USA.

Swaminathan Iyer (S)

MD Anderson Cancer Center, Houston, TX, USA.

Maen Abdelrahim (M)

Houston Methodist Hospital, Houston, TX, USA.

C L Beach (CL)

Celgene Corporation, Summit, NJ, USA.

Barry Skikne (B)

Celgene Corporation, Summit, NJ, USA.
University of Kansas Medical Center, Kansas City, KS, USA.

Eric Laille (E)

Celgene Corporation, Summit, NJ, USA.

Kao-Tai Tsai (KT)

Celgene Corporation, Summit, NJ, USA.

Thai Ho (T)

Mayo Clinic, Phoenix, AZ, USA.

Classifications MeSH