Challenges of neuropathic pain: focus on diabetic neuropathy.
Neuroinflammation
Painful diabetic neuropathy
Personalized pain management
Quantitative sensory testing
Spinal sensitization
Stratification in clinical trials
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
30
10
2019
accepted:
19
01
2020
pubmed:
10
2
2020
medline:
16
6
2021
entrez:
10
2
2020
Statut:
ppublish
Résumé
Neuropathic pain is a frequent condition caused by a lesion or disease of the central or peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain is diabetic neuropathy. Its complex pathophysiology is not yet fully elucidated, which contributes to underassessment and undertreatment. A mechanism-based treatment of painful diabetic neuropathy is challenging but phenotype-based stratification might be a way to develop individualized therapeutic concepts. Our goal is to review current knowledge of the pathophysiology of peripheral neuropathic pain, particularly painful diabetic neuropathy. We discuss state-of-the-art clinical assessment, validity of diagnostic and screening tools, and recommendations for the management of diabetic neuropathic pain including approaches towards personalized pain management. We also propose a research agenda for translational research including patient stratification for clinical trials and improved preclinical models in relation to current knowledge of underlying mechanisms.
Identifiants
pubmed: 32036431
doi: 10.1007/s00702-020-02145-7
pii: 10.1007/s00702-020-02145-7
pmc: PMC7148276
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
589-624Références
Diabetologia. 2001 Nov;44(11):1973-88
pubmed: 11719828
Pain. 2014 Nov;155(11):2263-73
pubmed: 25139589
Neurology. 1993 Apr;43(4):817-24
pubmed: 8469345
Cochrane Database Syst Rev. 2014 Feb 14;(2):CD009122
pubmed: 24526393
Eur J Neurol. 2010 Jul;17(7):903-12, e44-9
pubmed: 20642627
J Clin Invest. 2001 May;107(9):1083-92
pubmed: 11342572
Lancet Neurol. 2010 Aug;9(8):807-19
pubmed: 20650402
Diabetes. 2003 Oct;52(10):2615-22
pubmed: 14514647
Clin Neurophysiol. 2018 May;129(5):1011-1019
pubmed: 29567583
Pain Pract. 2017 Apr;17(4):514-521
pubmed: 27538385
Diabetes Care. 2006 Apr;29(4):883-7
pubmed: 16567832
J Pain Symptom Manage. 2005 Oct;30(4):374-85
pubmed: 16256902
Pain. 2016 Apr;157(4):791-6
pubmed: 26670465
Front Cell Neurosci. 2014 May 07;8:121
pubmed: 24847207
Brain. 2019 May 1;142(5):1215-1226
pubmed: 30887021
Diabetes Care. 2005 Aug;28(8):1869-75
pubmed: 16043725
J Diabetes Res. 2015;2015:547834
pubmed: 25961054
Eur J Neurol. 2010 Aug;17(8):1010-8
pubmed: 20298428
Cochrane Database Syst Rev. 2017 May 22;5:CD011669
pubmed: 28530786
Brain Behav. 2016 May 17;6(7):e00466
pubmed: 27458540
Diabetes Res Clin Pract. 2018 May;139:147-154
pubmed: 29518491
Diabetes Care. 2004 May;27(5):1047-53
pubmed: 15111519
PLoS One. 2017 Nov 30;12(11):e0187961
pubmed: 29190718
Curr Opin Neurol. 2009 Oct;22(5):467-74
pubmed: 19741531
Brain. 2015 Jan;138(Pt 1):2-3
pubmed: 25564488
J Diabetes Investig. 2018 Nov;9(6):1239-1254
pubmed: 29533535
Diabet Med. 2019 Jan;36(1):44-51
pubmed: 30102801
Mol Pain. 2007 Apr 03;3:9
pubmed: 17407590
Wellcome Open Res. 2018 May 29;3:63
pubmed: 30756091
Ann Intern Med. 2018 Apr 17;168(8):569-576
pubmed: 29507945
Diabetes Care. 2017 Apr;40(4):569-576
pubmed: 28174259
J Pain. 2009 Sep;10(9):895-926
pubmed: 19712899
Clin J Pain. 2003 Sep-Oct;19(5):306-14
pubmed: 12966256
Cochrane Database Syst Rev. 2017 Jun 09;6:CD007938
pubmed: 28597471
Nat Rev Neurol. 2017 Oct;13(10):624-638
pubmed: 28884750
Nat Rev Neurosci. 2018 Mar;19(3):138-152
pubmed: 29416128
Diabetes Care. 2009 Aug;32(8):1479-84
pubmed: 19470838
Pharmacol Res. 2019 Jan;139:1-16
pubmed: 30391353
Cochrane Database Syst Rev. 2017 Jun 15;6:CD003726
pubmed: 28616956
Neurology. 1999 Nov 10;53(8):1660-4
pubmed: 10563609
Annu Rev Neurosci. 2010;33:325-47
pubmed: 20367448
Brain. 2004 Jul;127(Pt 7):1593-605
pubmed: 15128619
Nat Neurosci. 2015 Aug;18(8):1081-3
pubmed: 26120961
Prog Brain Res. 2007;161:195-203
pubmed: 17618978
JAMA. 2003 Oct 1;290(13):1757-62
pubmed: 14519710
Nat Med. 2010 Nov;16(11):1267-76
pubmed: 20948535
Pain. 2012 Apr;153(4):765-74
pubmed: 22154921
Neurology. 2003 Mar 25;60(6):927-34
pubmed: 12654955
Acta Neurol Scand. 1991 Oct;84(4):326-33
pubmed: 1772006
Curr Pain Headache Rep. 2017 Jun;21(6):28
pubmed: 28432601
J Vasc Nurs. 2005 Sep;23(3):97-104
pubmed: 16125633
Brain Res. 2015 Oct 22;1624:515-524
pubmed: 26300222
J Diabetes. 2012 Sep;4(3):264-5
pubmed: 22507170
Brain Res Rev. 2009 Apr;60(1):84-9
pubmed: 19162069
Pain. 2017 Apr;158(4):560-568
pubmed: 27941499
Neurol Sci. 2011 Jun;32(3):423-6
pubmed: 21365294
Pain. 2013 Sep;154(9):1807-19
pubmed: 23742795
J Diabetes Investig. 2018 Sep;9(5):1173-1181
pubmed: 29430866
Cochrane Database Syst Rev. 2014 Jan 03;(1):CD007115
pubmed: 24385423
Neurology. 2009 Apr 28;72(17):1473-8
pubmed: 19246421
World J Diabetes. 2015 Apr 15;6(3):432-44
pubmed: 25897354
Foot Ankle Int. 2005 Jan;26(1):113-9
pubmed: 15680122
Diabet Med. 2014 Dec;31(12):1673-80
pubmed: 24975286
Pain. 2013 May;154(5):632-42
pubmed: 23318126
Exp Neurol. 1974 Jun;43(3):580-93
pubmed: 4827166
Pain. 2013 Dec;154 Suppl 1:S10-28
pubmed: 23792284
Ann Surg. 2013 Mar;257(3):403-12
pubmed: 23059501
J Pain Symptom Manage. 2000 Dec;20(6):449-58
pubmed: 11131263
Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(4):174-182
pubmed: 28413195
Handb Clin Neurol. 2014;126:353-77
pubmed: 25410234
Curr Opin Neurobiol. 2003 Jun;13(3):291-7
pubmed: 12850213
Pain. 2010 May;149(2):338-44
pubmed: 20227832
Diabetes Care. 2014 Dec;37(12):3253-61
pubmed: 25231896
Health Qual Life Outcomes. 2008 Aug 18;6:62
pubmed: 18706109
Korean J Physiol Pharmacol. 2019 Jan;23(1):1-20
pubmed: 30627005
Annu Rev Neurosci. 2009;32:1-32
pubmed: 19400724
Eur J Pain. 2017 Jan;21(1):29-44
pubmed: 27341614
Pain. 2011 Oct;152(10):2204-5
pubmed: 21764514
Nature. 2003 Aug 14;424(6950):778-83
pubmed: 12917686
Neuron. 2006 Oct 5;52(1):77-92
pubmed: 17015228
Eur J Pain. 2010 Apr;14(4):380-6
pubmed: 19726210
Joint Bone Spine. 2005 Oct;72(5):412-5
pubmed: 16214074
Brain Behav Immun. 2007 Jul;21(5):642-51
pubmed: 17174525
Diabetes Care. 2007 Oct;30(10):2608-12
pubmed: 17623821
Neurosci Lett. 2015 Jun 2;596:51-9
pubmed: 25556685
Metabolism. 2016 Apr;65(4):463-74
pubmed: 26975538
Pain. 2013 Aug;154(8):1197-203
pubmed: 23706627
Anesthesiology. 2018 Aug;129(2):343-366
pubmed: 29462012
Eur J Pain. 2011 May;15(5):441-3
pubmed: 21458336
Pain. 2016 Feb;157 Suppl 1:S72-80
pubmed: 26785159
J Neurosci. 2003 May 15;23(10):4017-22
pubmed: 12764087
Cell Rep. 2014 Jan 30;6(2):301-12
pubmed: 24440715
Pain. 2016 Feb;157 Suppl 1:S7-14
pubmed: 26785158
Curr Diab Rep. 2017 Oct 24;17(12):127
pubmed: 29064042
Lancet. 1998 Sep 12;352(9131):837-53
pubmed: 9742976
Diabetes Care. 2013 Oct;36(10):3208-15
pubmed: 23757426
Exp Ther Med. 2019 Mar;17(3):1963-1976
pubmed: 30783472
Pain. 2007 Dec 5;132(3):237-51
pubmed: 17920770
Pain. 2008 Jul;137(1):7-15
pubmed: 18410991
Pain. 2014 May;155(5):1002-15
pubmed: 24525274
J Hand Surg Am. 2017 Mar;42(3):166-174
pubmed: 28259273
J Pain. 2013 Nov;14(11):1255-69
pubmed: 24035349
Diabetes Care. 2003 Mar;26(3):770-6
pubmed: 12610036
J Neurol Sci. 2001 Aug 15;189(1-2):3-5
pubmed: 11596565
J Diabetes Complications. 2017 Apr;31(4):715-720
pubmed: 28159476
Anesth Analg. 2017 Nov;125(5):1638-1652
pubmed: 28537982
Curr Pain Headache Rep. 2010 Jun;14(3):203-12
pubmed: 20428975
Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1108-12
pubmed: 8577723
Lancet Neurol. 2012 Jun;11(6):521-34
pubmed: 22608666
Pain. 2011 Jan;152(1):14-27
pubmed: 20851519
Diabet Med. 2002 Nov;19(11):962-5
pubmed: 12421436
Diabetologia. 1992 Feb;35(2):155-9
pubmed: 1547920
Pain. 2010 Sep;150(3):573-81
pubmed: 20705215
Am J Med. 2004 Mar 1;116(5):318-24
pubmed: 14984817
Curr Med Res Opin. 2019 Jun;35(6):1011-1018
pubmed: 30479161
Nat Rev Dis Primers. 2019 Jun 13;5(1):41
pubmed: 31197153
Eur Neurol. 2015;74(5-6):323-7
pubmed: 26684759
Clin Neurol Neurosurg. 2006 Jul;108(5):477-81
pubmed: 16150538
Curr Med Res Opin. 2016;32(2):377-84
pubmed: 26641136
Pain. 2019 Jan;160(1):53-59
pubmed: 30586071
N Engl J Med. 2005 Jan 27;352(4):341-50
pubmed: 15673800
Cochrane Database Syst Rev. 2015 Jul 06;(7):CD008242
pubmed: 26146793
Pain. 2019 Jan;160(1):19-27
pubmed: 30586067
Cochrane Database Syst Rev. 2015 Aug 23;(8):CD011091
pubmed: 26298465
J Diabetes. 2018 Mar;10(3):192-199
pubmed: 28976724
Eur J Pain. 2009 Mar;13(3):263-72
pubmed: 18554968
Pain Ther. 2017 Dec;6(Suppl 1):35-42
pubmed: 29178033
Neurology. 1992 Jun;42(6):1164-70
pubmed: 1603343
Pain. 2018 Mar;159(3):569-575
pubmed: 29447136
Cochrane Database Syst Rev. 2012 Jun 13;(6):CD007543
pubmed: 22696371
Diabetes Care. 2005 Sep;28(9):2201-5
pubmed: 16123490
Diabetes Care. 2017 Jan;40(1):136-154
pubmed: 27999003
Am J Med. 2010 Mar;123(3 Suppl):S3-11
pubmed: 20206730
J Neurosci. 2013 Apr 10;33(15):6540-51
pubmed: 23575851
Pain. 2013 Nov;154(11):2249-61
pubmed: 23748119
Muscle Nerve. 2011 Sep;44(3):340-5
pubmed: 21996793
Diabetes Res Clin Pract. 2018 Oct;144:177-191
pubmed: 30201394
Diabet Med. 2003 May;20(5):368-74
pubmed: 12752485
Cochrane Database Syst Rev. 2007 Oct 17;(4):CD005454
pubmed: 17943857
J Neurosci Res. 2017 Jun;95(6):1330-1335
pubmed: 27574286
Anesthesiology. 2018 Nov;129(5):1015-1024
pubmed: 30199420
Pain. 2011 Mar;152(3 Suppl):S74-83
pubmed: 21185120
Stat Med. 2016 Oct 30;35(24):4427-4442
pubmed: 27311590
Pain. 2010 Dec;151(3):598-605
pubmed: 20965658
Diabetes Metab. 2009 Jun;35(3):206-13
pubmed: 19297223
J Neurobiol. 2004 Oct;61(1):55-71
pubmed: 15362153
Acta Neurochir (Wien). 2018 Dec;160(12):2509-2519
pubmed: 30293158
Neuroscience. 2018 Sep 1;387:28-37
pubmed: 28942323
Eur J Neurosci. 2014 Jun;39(11):1881-90
pubmed: 24888508
Diabetes Care. 2019 Mar;42(3):416-426
pubmed: 30104301
Pain. 2008 Aug 31;138(2):343-53
pubmed: 18289791
Clin Ther. 2005 Aug;27(8):1278-94
pubmed: 16199253
Pract Neurol. 2016 Feb;16(1):53-5
pubmed: 26392573
Clin J Pain. 2014 Jan;30(1):73-91
pubmed: 23446080
Neurol Sci. 2015 Dec;36(12):2169-75
pubmed: 26410087
Diabetes Care. 2003 Mar;26(3):697-701
pubmed: 12610024
Clin Neurophysiol. 2008 Aug;119(8):1705-1719
pubmed: 18486546
Pain. 2006 Aug;123(3):231-43
pubmed: 16697110
Musculoskelet Sci Pract. 2017 Aug;30:72-79
pubmed: 28600958
Korean J Physiol Pharmacol. 2014 Feb;18(1):1-14
pubmed: 24634591
Curr Pain Headache Rep. 2013 Sep;17(9):361
pubmed: 23943407
Diabetologia. 2005 Mar;48(3):578-85
pubmed: 15729579
Phys Med Rehabil Clin N Am. 2008 Feb;19(1):1-26, v
pubmed: 18194747
Nat Rev Neurosci. 2014 Jan;15(1):43-53
pubmed: 24281245
Prog Mol Biol Transl Sci. 2015;131:73-118
pubmed: 25744671
Fundam Clin Pharmacol. 2011 Feb;25(1):1-28
pubmed: 20030738
J Neurophysiol. 2016 Jul 1;116(1):159-70
pubmed: 27098028
Diabetes Care. 2002 Nov;25(11):2048-52
pubmed: 12401755
BMJ. 2014 May 06;348:g1799
pubmed: 24803311
Cell Rep. 2016 Dec 6;17(10):2753-2765
pubmed: 27926876
Mayo Clin Proc. 2016 Mar;91(3):372-85
pubmed: 26944242
PLoS One. 2017 Jul 18;12(7):e0180175
pubmed: 28719619
Pain. 2018 Jun;159(6):1090-1102
pubmed: 29494416
Pain. 2016 Mar;157(3):750-8
pubmed: 26630440
J Neurosci. 2005 Aug 10;25(32):7317-23
pubmed: 16093381
Exp Clin Endocrinol Diabetes. 2014 Feb;122(2):100-6
pubmed: 24554509
BMC Anesthesiol. 2016 Feb 18;16:12
pubmed: 26892406
Pain. 2007 Oct;131(3):243-57
pubmed: 17766042
Diabetes Res Clin Pract. 2016 Mar;113:101-7
pubmed: 26830855
Diabetes Care. 2018 May;41(5):1068-1075
pubmed: 29487078
Acta Neurol Taiwan. 2010 Jun;19(2):82-9
pubmed: 20714957
Braz J Phys Ther. 2018 May - Jun;22(3):222-230
pubmed: 29175181
Dis Mon. 2014 Jan;60(1):6-47
pubmed: 24507705
Pain. 2014 Oct;155(10):2171-9
pubmed: 25168665
Diabetes Care. 2004 Dec;27(12):2930-5
pubmed: 15562209
Cochrane Database Syst Rev. 2019 Jan 23;1:CD007076
pubmed: 30673120
J Neurol Sci. 2018 Jan 15;384:75-83
pubmed: 29249383
J Multidiscip Healthc. 2016 Sep 21;9:447-454
pubmed: 27703368
Pain. 2005 Jun;115(3):227-33
pubmed: 15876495
Physiol Rev. 2012 Jan;92(1):193-235
pubmed: 22298656
Expert Opin Pharmacother. 2014 Dec;15(18):2721-31
pubmed: 25381809
Skin Pharmacol Appl Skin Physiol. 2001 Jul-Aug;14(4):226-33
pubmed: 11464105
J Diabetes Res. 2017;2017:1467213
pubmed: 29250555
Pain. 2013 May;154(5):690-9
pubmed: 23485369
J Neurophysiol. 2006 Aug;96(2):579-90
pubmed: 16611846
Pain. 2013 Dec;154(12):2813-22
pubmed: 23973362
Diabetes Res Clin Pract. 2015 Aug;109(2):215-25
pubmed: 26008721
J Neurol Neurosurg Psychiatry. 2018 Oct;89(10):1082-1087
pubmed: 29627772
Pain. 2000 Mar;85(1-2):41-50
pubmed: 10692601
Arch Neurol. 2010 May;67(5):552-8
pubmed: 20457954
Biochim Biophys Acta. 2010 Oct;1802(10):924-33
pubmed: 19879943
Pain. 2005 Mar;114(1-2):29-36
pubmed: 15733628
J Neurosci Res. 2016 Jan;94(1):50-61
pubmed: 26423029
Rev Neurol (Paris). 2018 Dec;174(10):671-674
pubmed: 30054011
Brain Behav Immun. 2007 Jul;21(5):624-33
pubmed: 17267172
Neurology. 2003 Jan 28;60(2):297-300
pubmed: 12552048
J Pain Res. 2019 May 16;12:1537-1551
pubmed: 31190965
Brain. 2008 Jul;131(Pt 7):1912-25
pubmed: 18524793
J Neurophysiol. 2017 Oct 1;118(4):2059-2069
pubmed: 28615336
Diabetes Metab Res Rev. 2017 May;33(4):
pubmed: 28032668
Mol Pain. 2015 Mar 06;11:7
pubmed: 25885031
PLoS One. 2013 Sep 13;8(9):e74195
pubmed: 24058527
Pain. 2017 Jan;158(1):58-67
pubmed: 27780178
Nature. 2005 Dec 15;438(7070):1017-21
pubmed: 16355225
Nature. 1997 Oct 23;389(6653):816-24
pubmed: 9349813
ILAR J. 2014;54(3):259-72
pubmed: 24615439
Pain. 2004 Apr;108(3):248-57
pubmed: 15030944
Neuron. 2012 Feb 23;73(4):638-52
pubmed: 22365541
Neurology. 2016 Jul 12;87(2):220-8
pubmed: 27306631
Diabetes Care. 2008 Jan;31(1):140-5
pubmed: 17934147
Br J Pharmacol. 2018 Jun;175(12):2219-2230
pubmed: 28728214
Lancet Neurol. 2013 Nov;12(11):1084-95
pubmed: 24074723
Cell Rep. 2018 Feb 27;22(9):2307-2321
pubmed: 29490268
Pain. 2016 Feb;157 Suppl 1:S48-52
pubmed: 26785155
Curr Diab Rep. 2011 Aug;11(4):275-84
pubmed: 21611765
Lancet Neurol. 2014 Sep;13(9):924-35
pubmed: 25142459
BMC Neurol. 2018 Jun 29;18(1):91
pubmed: 29958535
J Diabetes Complications. 2016 May-Jun;30(4):716-22
pubmed: 26994558
CNS Drugs. 2008;22(5):417-42
pubmed: 18399710
Muscle Nerve. 2010 Aug;42(2):157-64
pubmed: 20658599
Pharmacol Rep. 2008 May-Jun;60(3):297-307
pubmed: 18622054
Eur J Pain. 2007 May;11(4):452-62
pubmed: 16889998
Nat Rev Neurosci. 2005 Jul;6(7):521-32
pubmed: 15995723
Pain. 2017 Dec;158(12):2340-2353
pubmed: 28858986
Neurology. 2014 Aug 12;83(7):628-37
pubmed: 25008392
Diabetes Res Clin Pract. 2001 Nov;54(2):115-28
pubmed: 11640995
Pain. 2014 Apr;155(4):828-32
pubmed: 24486884
Brain. 1953;76(4):594-624
pubmed: 13115576
Diabetes Care. 2010 Apr;33(4):721-7
pubmed: 20103550
Pain. 2008 Nov 15;140(1):209-23
pubmed: 18809257
Curr Med Res Opin. 2010 Oct;26(10):2411-9
pubmed: 20812792
Diabetes. 2016 Feb;65(2):331-45
pubmed: 26798119
Pain. 2014 Apr;155(4):654-62
pubmed: 24291734
Anesthesiology. 2015 Feb;122(2):399-406
pubmed: 25373391
Neurobiol Dis. 1998 Oct;5(4):209-27
pubmed: 9848092
Pain. 2015 Apr;156 Suppl 1:S104-14
pubmed: 25789426
Science. 2000 Jun 9;288(5472):1765-9
pubmed: 10846153
Pain. 2019 Jan;160(1):88-94
pubmed: 30586076
Pain Physician. 2004 Jul;7(3):365-75
pubmed: 16858476
J Neurophysiol. 1994 Oct;72(4):1570-87
pubmed: 7823087
Diabetes Care. 2001 Feb;24(2):250-6
pubmed: 11213874
Clin J Pain. 2007 Feb;23(2):150-8
pubmed: 17237664
Clin Drug Investig. 2015 Feb;35(2):95-108
pubmed: 25503082
Pain. 2003 Sep;105(1-2):71-8
pubmed: 14499422
Swiss Med Wkly. 2010 May 29;140(21-22):297-306
pubmed: 20458651
Diabetes Care. 2006 Nov;29(11):2365-70
pubmed: 17065669
Trends Neurosci. 2005 Feb;28(2):101-7
pubmed: 15667933
J Clin Invest. 2016 May 2;126(5):1983-97
pubmed: 27064281
Brain. 1983 Mar;106 (Pt 1):39-54
pubmed: 6831198
Pain Rep. 2017 Apr 20;2(3):e592
pubmed: 29392208
Diabetes Care. 2000 Jun;23(6):750-3
pubmed: 10840990
Eur J Pain. 2002;6 Suppl A:47-50
pubmed: 11888241
Nat Rev Neurol. 2017 Apr;13(4):203-216
pubmed: 28303912
Brain. 2015 Jan;138(Pt 1):43-52
pubmed: 25392197
BMC Neurol. 2016 Dec 6;16(1):251
pubmed: 27919222
World J Diabetes. 2014 Aug 15;5(4):546-56
pubmed: 25126400
Pain. 1990 Aug;42(2):131-7
pubmed: 1701044
Mol Pain. 2019 Jan-Dec;15:1744806919858801
pubmed: 31172839
Pain. 2016 Jan;157(1):30-54
pubmed: 26218719
Science. 1972 May 5;176(4034):482-8
pubmed: 5032347
Pain. 2016 Nov;157(11):2410-2419
pubmed: 27559835
Trends Neurosci. 2003 Dec;26(12):696-705
pubmed: 14624855
Pain. 2016 May;157(5):1132-45
pubmed: 27088890
J Pain. 2015 Jul;16(7):616-27
pubmed: 25843054
Diabetes Res Clin Pract. 2018 Dec;146:191-201
pubmed: 30389624
Pain. 2019 Nov;160(11):2497-2507
pubmed: 31219946
Pharmaceuticals (Basel). 2016 Nov 14;9(4):
pubmed: 27854251
J Neurosci. 2004 Jan 28;24(4):964-71
pubmed: 14749441
Pain. 2009 Jun;143(3):169-71
pubmed: 19362418
Pediatr Neurol. 2013 Sep;49(3):171-7
pubmed: 23831248
Pain. 2009 Nov;146(1-2):5-6
pubmed: 19625126
Pharmacol Ther. 2018 Apr;184:145-158
pubmed: 28987324
Semin Neurol. 2016 Oct;36(5):462-468
pubmed: 27704502
Diabetes Technol Ther. 2005 Jun;7(3):497-508
pubmed: 15929681
J Neurosci. 2001 Mar 15;21(6):1868-75
pubmed: 11245671
Cochrane Database Syst Rev. 2017 Dec 02;12:CD007963
pubmed: 29199767
Neuroimage. 2007;37 Suppl 1:S80-8
pubmed: 17512757
Diabetes Care. 2010 May;33(5):1090-6
pubmed: 20150297
Neurology. 2008 Apr 29;70(18):1630-5
pubmed: 18003941
Pharmacol Ther. 2008 Oct;120(1):1-34
pubmed: 18616962
Curr Drug Targets. 2008 Jan;9(1):3-13
pubmed: 18220709
Ann Neurol. 1980 Dec;8(6):590-6
pubmed: 7212646
Pain. 2018 Dec;159(12):2658-2666
pubmed: 30161042
J Pain Palliat Care Pharmacother. 2016;30(1):31-5
pubmed: 25700217
Nat Med. 2010 Nov;16(11):1248-57
pubmed: 20948530
Nature. 1992 Apr 9;356(6369):521-3
pubmed: 1373227
Lancet Neurol. 2012 Nov;11(11):999-1005
pubmed: 23079556
Pain. 2008 Jun;136(3):380-7
pubmed: 17888574
Am Fam Physician. 2016 Aug 1;94(3):227-34
pubmed: 27479625
Nat Neurosci. 2007 Nov;10(11):1361-8
pubmed: 17965656
Annu Rev Pharmacol Toxicol. 2004;44:371-97
pubmed: 14744251
Lancet Neurol. 2018 May;17(5):456-466
pubmed: 29598922
Muscle Nerve. 1988 Jan;11(1):21-32
pubmed: 3277049
Cochrane Database Syst Rev. 2014 Apr 27;(4):CD007938
pubmed: 24771480
Curr Med Res Opin. 2006 Oct;22(10):1911-20
pubmed: 17022849
Mini Rev Med Chem. 2016;16(2):120-62
pubmed: 26349493
Pain. 2019 Sep;160(9):1967-1975
pubmed: 30985621
Diabetes Care. 1994 Nov;17(11):1281-9
pubmed: 7821168
Exp Brain Res. 2009 Jun;196(1):115-28
pubmed: 19242687
Neurology. 2011 May 17;76(20):1758-65
pubmed: 21482920
Foot Ankle Surg. 2008;14(3):120-4
pubmed: 19083628
Nat Med. 2017 Sep 8;23(9):1018-1027
pubmed: 28886007
Diabetes Care. 2010 Oct;33(10):2285-93
pubmed: 20876709
Pain. 2017 Jun;158(6):1100-1107
pubmed: 28267059
J Neuroimmunol. 2008 Jul 31;198(1-2):113-20
pubmed: 18547654
Curr Pain Headache Rep. 2012 Jun;16(3):191-8
pubmed: 22395856
Pain. 2012 Jun;153(6):1193-8
pubmed: 22480803
J Pain. 2013 Sep;14(9):941-7
pubmed: 23685187
J Neurosci. 2003 Feb 15;23(4):1169-78
pubmed: 12598605
J Comp Neurol. 2000 Jun 26;422(2):172-80
pubmed: 10842225
J Pharmacol Exp Ther. 2003 Aug;306(2):624-30
pubmed: 12734393
Science. 2012 Jan 13;335(6065):235-8
pubmed: 22246779
Pain. 2014 Jul;155(7):1272-9
pubmed: 24704366
J Pain. 2017 Apr;18(4):415-427
pubmed: 27986591
Diabet Med. 2009 Mar;26(3):240-6
pubmed: 19317818
Diabetes. 2007 Aug;56(8):2148-54
pubmed: 17513704
Exp Clin Endocrinol Diabetes. 2008 Nov;116(10):600-5
pubmed: 18473286
J Diabetes Complications. 2015 Mar;29(2):212-7
pubmed: 25498300
Cochrane Database Syst Rev. 2014 Sep 23;(9):CD011003
pubmed: 25246131
Pain. 2008 Jul 31;137(3):473-7
pubmed: 18583048
BMJ. 2010 Mar 24;340:c1079
pubmed: 20335333
Cochrane Database Syst Rev. 2012 Jul 11;(7):CD008943
pubmed: 22786518
Diabetes Care. 2011 Oct;34(10):2220-4
pubmed: 21852677
Nat Med. 2012 Jun;18(6):926-33
pubmed: 22581285
Pain. 2016 Sep;157(9):1851-71
pubmed: 27152687
J Pain Res. 2018 Jul 10;11:1307-1318
pubmed: 30022849
Clin J Pain. 2009 Jun;25(5):376-85
pubmed: 19454870
Pain. 2005 Jun;115(3):254-63
pubmed: 15911152
Nat Clin Pract Neurol. 2006 Feb;2(2):95-106
pubmed: 16932531
Pain. 2016 Aug;157(8):1599-606
pubmed: 27115670
Pain. 1986 Jan;24(1):57-65
pubmed: 2937007
Toxicon. 2018 Jun 1;147:120-128
pubmed: 29409817
Toxins (Basel). 2017 Aug 24;9(9):
pubmed: 28837075
Eur J Pharmacol. 2018 Aug 15;833:472-523
pubmed: 29966615
Pain Manag. 2012 Jan;2(1):71-7
pubmed: 24654620
Lancet. 2010 Aug 7;376(9739):419-30
pubmed: 20594588
J Neurol. 2009 Jul;256(7):1067-75
pubmed: 19252773
J Diabetes Complications. 2007 Jan-Feb;21(1):13-9
pubmed: 17189869
J Pain. 2008 Apr;9(4):350-9
pubmed: 18226963
Pain Med. 2017 Oct 1;18(10):1999-2012
pubmed: 27837032
Nat Neurosci. 1999 Apr;2(4):331-8
pubmed: 10204539
Pain. 2012 Sep;153(9):1815-23
pubmed: 22683276
J Pain. 2006 May;7(5 Suppl 3):S1-29
pubmed: 16632328
J Neurophysiol. 2013 Apr;109(7):1775-81
pubmed: 23303860
Eur J Pharmacol. 2006 Jan 13;530(1-2):48-53
pubmed: 16359659
Pain Res Manag. 2014 Nov-Dec;19(6):328-35
pubmed: 25479151
Diabet Med. 2012 May;29(5):578-85
pubmed: 22023377
Pain. 2012 Jan;153(1):42-55
pubmed: 21993185
Cochrane Database Syst Rev. 2007 Oct 17;(4):CD004572
pubmed: 17943821
Mol Pain. 2007 Sep 27;3:27
pubmed: 17900333
N Engl J Med. 2017 Aug 3;377(5):411-414
pubmed: 28767350
Pain. 1992 Nov;51(2):175-94
pubmed: 1484715
J Neurol. 2018 Feb;265(2):231-238
pubmed: 29032407
J Neurosci. 2008 Oct 22;28(43):11079-88
pubmed: 18945915
Nature. 1992 Jan 2;355(6355):75-8
pubmed: 1370574
Pain. 2019 May;160 Suppl 1:S66-S69
pubmed: 31008852
Int J Endocrinol. 2018 Mar 15;2018:8641942
pubmed: 29736170
Exp Neurol. 2012 Apr;234(2):283-92
pubmed: 21946268
Radiat Res. 2017 Oct;188(4):455-462
pubmed: 28796579
Lancet Neurol. 2014 Jun;13(6):587-99
pubmed: 24813307
Cochrane Database Syst Rev. 2017 Jan 13;1:CD007393
pubmed: 28085183
Nature. 2006 Dec 14;444(7121):894-8
pubmed: 17167479
J Neurosci. 2002 Aug 1;22(15):6724-31
pubmed: 12151551
Lancet Neurol. 2015 Feb;14(2):162-73
pubmed: 25575710
Pain. 2018 Mar;159(3):583-594
pubmed: 29240606
Arch Phys Med Rehabil. 2005 Jan;86(1):167-74
pubmed: 15641009
Pain. 2017 Feb;158(2):261-272
pubmed: 27893485
Nat Rev Dis Primers. 2017 Feb 16;3:17002
pubmed: 28205574
Mol Med Rep. 2017 Jan;15(1):89-96
pubmed: 27959414
Cochrane Database Syst Rev. 2014 May 19;(5):CD010769
pubmed: 24838845
Pain. 2016 Jul;157(7):1382-6
pubmed: 26835783
Clin Ther. 2017 Jun;39(6):1104-1122
pubmed: 28554532
Muscle Nerve. 2008 Jan;37(1):50-60
pubmed: 17763459
Int J Neurosci. 2015 Mar;125(3):170-4
pubmed: 24831263
Diabetologia. 1984 Dec;27(6):563-7
pubmed: 6530051
Neuron. 2009 Oct 15;64(1):46-54
pubmed: 19840548
Eur J Pain. 2013 Aug;17(7):953-6
pubmed: 23339030
Pain. 2018 Mar;159(3):469-480
pubmed: 29176367
J Neurosci. 2003 Apr 1;23(7):2517-21
pubmed: 12684435
Pain. 2017 Dec;158(12):2487-2495
pubmed: 28930774
J Neuroimmunol. 2008 Mar;195(1-2):157-63
pubmed: 18325600
Eur J Neurol. 2010 Sep;17(9):1113-e88
pubmed: 20402746
Pain. 2018 May;159(5):968-977
pubmed: 29419657
Neuron. 2017 Mar 22;93(6):1296-1313
pubmed: 28334605
Am J Med. 2009 Oct;122(10 Suppl):S13-21
pubmed: 19801048
Exp Clin Endocrinol Diabetes. 2014 Jul;122(7):406-15
pubmed: 25014092
J Clin Epidemiol. 2015 Aug;68(8):957-66
pubmed: 25895961
JAMA Intern Med. 2016 Mar;176(3):300-1
pubmed: 26882223
Front Neurosci. 2016 Dec 23;10:581
pubmed: 28066166
Mayo Clin Proc. 2010 Mar;85(3 Suppl):S3-14
pubmed: 20194146
J Diabetes Investig. 2011 Jan 24;2(1):18-32
pubmed: 24843457
Diabetes Metab Syndr. 2016 Jan-Mar;10(1):48-60
pubmed: 26072202
Curr Diab Rep. 2015 Nov;15(11):89
pubmed: 26370700