Analysis of choroidal thickness and vascularity in patients with unilateral polypoidal choroidal vasculopathy.
Aged
Choroid
/ blood supply
Choroidal Neovascularization
/ diagnosis
Coloring Agents
/ administration & dosage
Female
Fluorescein Angiography
Follow-Up Studies
Humans
Indocyanine Green
/ administration & dosage
Male
Middle Aged
Organ Size
Polyps
/ diagnosis
Retrospective Studies
Slit Lamp Microscopy
Tomography, Optical Coherence
Visual Acuity
/ physiology
Choroidal thickness
Choroidal vascularity index
Dilated Haller vessel
Pachychoroid
Polypoidal choroidal vasculopathy
Journal
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
ISSN: 1435-702X
Titre abrégé: Graefes Arch Clin Exp Ophthalmol
Pays: Germany
ID NLM: 8205248
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
18
09
2019
accepted:
02
02
2020
revised:
13
01
2020
pubmed:
11
2
2020
medline:
7
4
2021
entrez:
11
2
2020
Statut:
ppublish
Résumé
This study aimed to analyze the choroidal characteristics in eyes with polypoidal choroidal vasculopathy (PCV, affected eyes) and unaffected fellow eyes, and investigated the longitudinal changes in the choroidal structure of fellow eyes in patients with unilateral PCV. We retrospectively reviewed the medical records of 55 treatment-naïve patients with unilateral PCV. The choroidal thickness and vascularity between PCV affected eyes, unaffected fellow eyes, and normal control eyes were compared. Structural changes in the choroid of the fellow eyes were reviewed during follow-up. PCV eyes had thicker subfoveal choroidal thickness (SFCT) (p < 0.001), greater ratio of Haller layer to SFCT (p < 0.001), and lower choroidal vascularity index (p = 0.023), compared to controls. In unaffected fellow eyes, the ratio of the Haller layer to SFCT was greater (p < 0.001) than in controls. During a 58.91-month mean follow-up, nine (16%) fellow eyes developed new PCV. These eyes showed a greater ratio of Haller layer to SFCT at baseline (p < 0.001) compared to the other fellow eyes. We also observed a numerical change in the choroidal vascularity index during follow-up of fellow eyes that developed new PCV. The dilation of the Haller layer was prominent in PCV eyes and fellow eyes, compared to normal controls. In the fellow eyes that developed new PCV lesions, there were changes in the choroidal vascularity during follow-up.
Identifiants
pubmed: 32037487
doi: 10.1007/s00417-020-04620-z
pii: 10.1007/s00417-020-04620-z
doi:
Substances chimiques
Coloring Agents
0
Indocyanine Green
IX6J1063HV
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1157-1164Subventions
Organisme : Ministry of Education
ID : 2016R1A6A1A03010528
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