Nonrapid eye movement sleep and risk for autism spectrum disorder in early development: A topographical electroencephalogram pilot study.
autism spectrum disorder
high-density electroencephalogram
infants
nonrapid eye movement sleep
sleep spindles
theta
toddlers
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
29
07
2019
revised:
10
11
2019
accepted:
03
01
2020
pubmed:
11
2
2020
medline:
18
3
2021
entrez:
11
2
2020
Statut:
ppublish
Résumé
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that emerges in the beginning years of life (12-48 months). Yet, an early diagnosis of ASD is challenging as it relies on the consistent presence of behavioral symptomatology, and thus, many children are diagnosed later in development, which prevents early interventions that could benefit cognitive and social outcomes. As a result, there is growing interest in detecting early brain markers of ASD, such as in the electroencephalogram (EEG) to elucidate divergence in early development. Here, we examine the EEG of nonrapid eye movement (NREM) sleep in the transition from infancy to toddlerhood, a period of rapid development and pronounced changes in early brain function. NREM features exhibit clear developmental trajectories, are related to social and cognitive development, and may be altered in neurodevelopmental disorders. Yet, spectral features of NREM sleep are poorly understood in infants/toddlers with or at high risk for ASD. The present pilot study is the first to examine NREM sleep in 13- to 30-month-olds with ASD in comparison with age-matched healthy controls (TD). EEG was recorded during a daytime nap with high-density array EEG. We found topographically distinct decreased fast theta oscillations (5-7.25 Hz), decreased fast sigma (15-16 Hz), and increased beta oscillations (20-25 Hz) in ASD compared to TD. These findings suggest a possible functional role of NREM sleep during this important developmental period and provide support for NREM sleep to be a potential early marker for ASD.
Identifiants
pubmed: 32037734
doi: 10.1002/brb3.1557
pmc: PMC7066345
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e01557Subventions
Organisme : UNC Psychiatry
Pays : International
Organisme : NIBIB NIH HHS
ID : R01 EB016407
Pays : United States
Organisme : Swiss National Science Foundation
ID : P3P3PA_171525
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : P300PA_164693
Pays : Switzerland
Organisme : UNC School of Medicine
Pays : International
Organisme : NIMH NIH HHS
ID : R01 MH101547
Pays : United States
Organisme : North Carolina Translational NC TraCS
ID : 2KR721505
Pays : International
Informations de copyright
© 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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