Predictors of Metabolic Syndrome among Polycystic Ovary Syndrome Sisters.
Metabolic syndrome
PCOS
PCOS sisters
Journal
Journal of human reproductive sciences
ISSN: 0974-1208
Titre abrégé: J Hum Reprod Sci
Pays: India
ID NLM: 101473512
Informations de publication
Date de publication:
Historique:
received:
31
12
2018
revised:
15
04
2019
accepted:
24
09
2019
entrez:
11
2
2020
pubmed:
11
2
2020
medline:
11
2
2020
Statut:
ppublish
Résumé
Metabolic syndrome among PCOS sisters may vary depending on the phenotype. The aim of the present study was to analyze the prevalence of metabolic syndrome among different phenotypes of PCOS sisters. Case control study. Two hundred sisters of PCOS patients and 99 age matched healthy controls underwent history, clinical examination, biochemical parameters for metabolic syndrome and hormonal assessment. Of 200 sisters, 85 were unaffected (UA group), 21 sisters had hyperandrogenemia (HA group), and 94 sisters had irregular periods or hyperandrogenemia. We observed that the frequency of metabolic syndrome among PCOS sisters was comparable to age and weight matched controls (30% vs 27%). The prevalence of metabolic syndrome was higher in HA and AFFECTED sisters (around 30% in both) compared to UA sisters (20%). The presence of metabolic syndrome was significantly associated with age, BMI, HOMA-IR and free testosterone. After correction for age and BMI, metabolic syndrome was significantly associated with HOMA-IR ( Based on above findings, we conclude that affected sisters and those with higher age, BMI and hyperandrogenemia have a high risk of metabolic syndrome compared to unaffected sisters.
Identifiants
pubmed: 32038085
doi: 10.4103/jhrs.JHRS_172_18
pii: JHRS-12-334
pmc: PMC6937762
doi:
Types de publication
Journal Article
Langues
eng
Pagination
334-340Informations de copyright
Copyright: © 2019 Journal of Human Reproductive Sciences.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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