Identification of a Selective PDE4B Inhibitor From

Bryophyllum pinnatum Flavonoid PDE4 inverse virtual screening molecular dynamics natural products

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2019
Historique:
received: 26 08 2019
accepted: 05 12 2019
entrez: 11 2 2020
pubmed: 11 2 2020
medline: 11 2 2020
Statut: epublish

Résumé

Natural products are considered an important source of bioactive compounds especially in biodiversity-rich countries like Brazil. The identification of potential targets is crucial to the development of drugs from natural sources. In this context,

Identifiants

pubmed: 32038254
doi: 10.3389/fphar.2019.01582
pmc: PMC6987432
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1582

Informations de copyright

Copyright © 2020 Lourenço, Fernandes, Carvalho, Grougnet, Martins, Jordão, Zucolotto and Barbosa.

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Auteurs

Estela M G Lourenço (EMG)

Laboratório de Química Farmacêutica Computacional, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, Brazil.

Júlia M Fernandes (JM)

Laboratório de Produtos Naturais Bioativos, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, Brazil.

Vinícius de F Carvalho (VF)

Laboratório de Inflamação, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Raphael Grougnet (R)

Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université Paris Descartes, Paris, France.

Marco A Martins (MA)

Laboratório de Inflamação, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Alessandro K Jordão (AK)

Laboratório de Química Farmacêutica Computacional, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, Brazil.

Silvana M Zucolotto (SM)

Laboratório de Produtos Naturais Bioativos, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, Brazil.

Euzébio G Barbosa (EG)

Laboratório de Química Farmacêutica Computacional, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, Brazil.

Classifications MeSH