Controversies in the management of hepatocellular carcinoma.
Diagnosis
Hepatocelullar carcinoma
Liver transplantation
Locoregional therapy
Surgery
Systemic therapy
Journal
JHEP reports : innovation in hepatology
ISSN: 2589-5559
Titre abrégé: JHEP Rep
Pays: Netherlands
ID NLM: 101761237
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
12
12
2018
revised:
11
01
2019
accepted:
13
01
2019
entrez:
11
2
2020
pubmed:
11
2
2020
medline:
11
2
2020
Statut:
epublish
Résumé
The management of hepatocellular carcinoma (HCC) has evolved considerably over the last decade. Surveillance of cirrhotic patients and refinements to imaging techniques have enabled a relevant proportion of patients to be diagnosed at an early stage, when effective therapies are feasible. Resection, transplantation and ablation are all options in patients with early stage HCC. Thus, there is some controversy regarding which is the best treatment approach in challenging scenarios. There have also been major developments in locoregional therapies, particularly in intra-arterial approaches. Finally, the systemic treatment for HCC has changed dramatically following the demonstration of a survival benefit with sorafenib; there are currently several first-line (sorafenib and lenvatinib) and second-line (regorafenib, cabozantinib and ramucirumab) treatments that have shown a survival benefit. Expectations for immune checkpoint inhibitors are high, with the results of the ongoing phase III trials eagerly awaited. In this review we discuss some of the controversies in the management of HCC, focussing in particular on systemic therapy.
Identifiants
pubmed: 32039350
doi: 10.1016/j.jhepr.2019.02.003
pii: S2589-5559(19)30002-3
pmc: PMC7001551
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
17-29Informations de copyright
© 2019 The Authors.
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