Immunobiology of cholangiocarcinoma.
Distal cholangiocarcinoma
immune checkpoint blockade
immune cold CCA
immune hot CCA
intrahepatic cholangiocarcinoma
perihilar cholangiocarcinoma
Journal
JHEP reports : innovation in hepatology
ISSN: 2589-5559
Titre abrégé: JHEP Rep
Pays: Netherlands
ID NLM: 101761237
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
17
05
2019
revised:
21
06
2019
accepted:
22
06
2019
entrez:
11
2
2020
pubmed:
11
2
2020
medline:
11
2
2020
Statut:
epublish
Résumé
Cholangiocarcinoma (CCA) represents a heterogeneous group of epithelial tumours that are classified according to anatomical location as intrahepatic (iCCA), perihilar (pCCA), or distal (dCCA). Although surgical resection and liver transplantation following neoadjuvant therapy are potentially curative options for a subset of patients with early-stage disease, the currently available medical therapies for CCA have limited efficacy. Immunotherapeutic strategies such as immune checkpoint blockade (ICB) harness the host immune system to unleash an effective and durable antitumour response in a subset of patients with a variety of malignancies. However, response to ICB monotherapy has been relatively disappointing in CCA. CCAs are desmoplastic tumours with an abundant tumour immune microenvironment (TIME) that contains immunosuppressive innate immune cells such as tumour-associated macrophages and myeloid-derived suppressor cells. A subset of CCAs may be classified as immune 'hot' tumours with a high density of CD8
Identifiants
pubmed: 32039381
doi: 10.1016/j.jhepr.2019.06.003
pii: S2589-5559(19)30060-6
pmc: PMC7001542
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
297-311Subventions
Organisme : NCI NIH HHS
ID : P50 CA210964
Pays : United States
Informations de copyright
© 2019 The Authors.
Références
J Immunol. 2002 Jan 15;168(2):689-95
pubmed: 11777962
Cancer Ther. 2008;6(B):955-964
pubmed: 19129927
Nat Immunol. 2012 Dec;13(12):1145-54
pubmed: 23160217
Nat Rev Cancer. 2019 Mar;19(3):133-150
pubmed: 30755690
Science. 2014 May 23;344(6186):921-5
pubmed: 24812208
J Clin Invest. 2013 Apr;123(4):1444-56
pubmed: 23524967
Nat Genet. 2015 Sep;47(9):1003-10
pubmed: 26258846
Nat Rev Gastroenterol Hepatol. 2016 May;13(5):261-80
pubmed: 27095655
Oncotarget. 2016 Aug 9;7(32):50963-50971
pubmed: 26918355
Cancer Sci. 2016 Feb;107(2):116-22
pubmed: 26608587
Sci Transl Med. 2018 Jan 17;10(424):
pubmed: 29343622
Cancer Res. 1998 Dec 1;58(23):5344-7
pubmed: 9850063
Br J Cancer. 2018 Jan;118(2):171-180
pubmed: 29123259
Cancer Res. 2017 Jul 1;77(13):3666-3671
pubmed: 28446466
J Clin Oncol. 2015 Sep 1;33(25):2780-8
pubmed: 26014293
World J Gastroenterol. 2015 Apr 28;21(16):4961-8
pubmed: 25945010
World J Gastroenterol. 2006 Dec 7;12(45):7233-8
pubmed: 17143936
Clin Cancer Res. 2017 Sep 1;23(17):5187-5201
pubmed: 28698201
Cancer Res. 2014 Sep 15;74(18):5057-69
pubmed: 25082815
J Clin Oncol. 2019 Feb 1;37(4):318-327
pubmed: 30557521
Cell Mol Immunol. 2016 May;13(3):267-76
pubmed: 27063467
N Engl J Med. 2017 Dec 21;377(25):2503-2504
pubmed: 29262279
Cancer Res. 2013 Apr 15;73(8):2435-44
pubmed: 23423978
J Hepatobiliary Pancreat Sci. 2012 Mar;19(2):171-8
pubmed: 21874278
J Clin Invest. 2016 Oct 3;126(10):3672-3679
pubmed: 27482883
Hepatology. 2019 May;69(5):2048-2060
pubmed: 30578687
Hepatology. 2012 Jan;55(1):86-97
pubmed: 21898484
Hum Pathol. 2004 Jul;35(7):881-6
pubmed: 15257553
Hepatology. 2019 Jul;70(1):198-214
pubmed: 30810243
Cancer Gene Ther. 2015 Dec;22(12):591-6
pubmed: 26584530
JAMA. 2014 Nov 5;312(17):1744-53
pubmed: 25369488
Clin Cancer Res. 2009 Oct 1;15(19):6225-31
pubmed: 19755389
J Clin Oncol. 2006 Jul 1;24(19):3164-71
pubmed: 16809739
J Biol Chem. 2016 Jan 1;291(1):149-59
pubmed: 26527689
Immunity. 2010 Jun 25;32(6):790-802
pubmed: 20605485
Anticancer Res. 2005 Sep-Oct;25(5):3575-9
pubmed: 16101182
Nat Rev Immunol. 2007 Jul;7(7):543-55
pubmed: 17589544
Cancer Res. 2009 Jul 1;69(13):5514-21
pubmed: 19549903
J Hepatol. 2014 May;60(5):1090-6
pubmed: 24412603
J Clin Invest. 2018 Aug 1;128(8):3209-3218
pubmed: 30067248
Oncoimmunology. 2016 Sep 20;5(11):e1234565
pubmed: 27999748
Anticancer Res. 2017 Jan;37(1):183-190
pubmed: 28011489
Gastroenterology. 2005 May;128(6):1655-67
pubmed: 15887157
Hepatobiliary Pancreat Dis Int. 2016 Feb;15(1):99-105
pubmed: 26818550
Nat Rev Clin Oncol. 2018 Feb;15(2):95-111
pubmed: 28994423
Cancer Gene Ther. 2006 Mar;13(3):326-34
pubmed: 16138120
J Gastrointest Surg. 2013 Sep;17(9):1609-17
pubmed: 23877328
Oncologist. 2018 Dec;23(12):1407-e136
pubmed: 29853658
Clin Cancer Res. 2005 Sep 15;11(18):6713-21
pubmed: 16166452
Biochem Biophys Res Commun. 2015 Mar 6;458(2):234-9
pubmed: 25623530
Clin Cancer Res. 2009 Sep 1;15(17):5323-37
pubmed: 19723653
Cancer Sci. 2010 Aug;101(8):1913-9
pubmed: 20545696
J Clin Invest. 2015 Mar 2;125(3):1269-85
pubmed: 25689248
Radiother Oncol. 2015 Oct;117(1):165-70
pubmed: 26235847
In Vivo. 2018 Jul-Aug;32(4):771-781
pubmed: 29936458
Front Immunol. 2018 Mar 02;9:398
pubmed: 29552012
Cancer Discov. 2018 Sep;8(9):1069-1086
pubmed: 30115704
J Surg Oncol. 2009 Nov 1;100(6):500-4
pubmed: 19697355
Cancer Res. 2013 Feb 1;73(3):1128-41
pubmed: 23221383
J Hematol Oncol. 2017 Jan 5;10(1):4
pubmed: 28057014
J Exp Med. 2000 Nov 6;192(9):1213-22
pubmed: 11067871
Cell. 2016 Apr 21;165(3):668-78
pubmed: 27062926
BMC Cancer. 2015 Oct 24;15:790
pubmed: 26497197
Cancer Immunol Immunother. 2003 Jul;52(7):423-8
pubmed: 12695859
Nat Med. 2018 May;24(5):541-550
pubmed: 29686425
JAMA Oncol. 2019 Jun 01;5(6):824-830
pubmed: 30998813
Lancet. 2008 Jul 12;372(9633):117-126
pubmed: 18620949
Science. 2014 May 9;344(6184):641-5
pubmed: 24812403
Oncoimmunology. 2015 Mar 19;4(6):e1008371
pubmed: 26155418
Cancer Immunol Res. 2017 Jan;5(1):3-8
pubmed: 28052991
J Transl Med. 2014 Mar 07;12:61
pubmed: 24606884
Gastroenterology. 2009 Apr;136(4):1134-44
pubmed: 19245868
Ann Surg Oncol. 2016 Aug;23(8):2610-7
pubmed: 27012989
J Hepatol. 2017 Jan;66(1):102-115
pubmed: 27593106
Cancer Res. 2010 Jan 1;70(1):68-77
pubmed: 20028852
J Clin Oncol. 2018 Feb 1;36(4):359-366
pubmed: 29232172
Cell Mol Gastroenterol Hepatol. 2019;7(2):371-390
pubmed: 30704985
Int J Oncol. 2006 Nov;29(5):1319-29
pubmed: 17016667
Cancer Res. 2010 Apr 15;70(8):3052-61
pubmed: 20388795
Cancer Res. 1998 Aug 15;58(16):3491-4
pubmed: 9721846
J Surg Oncol. 2003 Dec;84(4):224-8
pubmed: 14756433
Exp Ther Med. 2012 Mar;3(3):463-469
pubmed: 22969912
Annu Rev Immunol. 2015;33:445-74
pubmed: 25622193
Sci Transl Med. 2014 May 21;6(237):237ra67
pubmed: 24848257
Oncoimmunology. 2017 Jun 28;6(8):e1331806
pubmed: 28919993
Cancer Cell. 2017 Jun 12;31(6):771-789.e6
pubmed: 28609656
N Engl J Med. 2017 Oct 5;377(14):1345-1356
pubmed: 28889792
Ann Thorac Surg. 2000 Nov;70(5):1634-40
pubmed: 11093500
J Exp Med. 2018 Mar 5;215(3):859-876
pubmed: 29436396
World J Gastroenterol. 2009 Oct 28;15(40):5053-7
pubmed: 19859998
Gastroenterology. 2013 Dec;145(6):1215-29
pubmed: 24140396
Cancer Manag Res. 2018 Oct 02;10:4113-4123
pubmed: 30323667
Hepatology. 2006 Feb;43(2 Suppl 1):S54-62
pubmed: 16447271
Gut. 2018 May;67(5):931-944
pubmed: 28939663
Cancer Res. 2012 Aug 15;72(16):3977-86
pubmed: 22719066
Anticancer Res. 2012 Jun;32(6):2249-56
pubmed: 22641659
Hepatology. 2009 Sep;50(3):799-807
pubmed: 19551844
Ann Surg Oncol. 2016 Jan;23(1):235-43
pubmed: 26059651
J Immunother Cancer. 2017 Dec 19;5(1):101
pubmed: 29254508
J Immunother. 2011 Jan;34(1):92-9
pubmed: 21150717
Cytometry B Clin Cytom. 2019 Nov;96(6):490-495
pubmed: 30828998
N Engl J Med. 2010 Jul 29;363(5):411-22
pubmed: 20818862
Immunity. 2016 Feb 16;44(2):303-15
pubmed: 26885857
Oncotarget. 2017 Apr 11;8(15):24644-24651
pubmed: 28445951
Oncotarget. 2018 May 4;9(34):23366-23372
pubmed: 29805739
Immunol Rev. 2012 Sep;249(1):158-75
pubmed: 22889221
J Exp Med. 2012 Sep 24;209(10):1869-82
pubmed: 22927549
Immunity. 2017 Aug 15;47(2):374-388.e6
pubmed: 28813662
Sci Immunol. 2016 Aug;1(2):
pubmed: 28417112
J Immunother Cancer. 2018 Aug 6;6(1):78
pubmed: 30081947
Eur J Immunol. 2006 Nov;36(11):2960-70
pubmed: 17039564
Hepatology. 2008 Jan;47(1):90-6
pubmed: 18023027
PLoS One. 2016 Oct 25;11(10):e0164514
pubmed: 27780254
Br J Cancer. 2010 Jan 5;102(1):68-72
pubmed: 19935794
J Hepatol. 2019 Jul;71(1):104-114
pubmed: 30910538
Br J Cancer. 2013 Nov 12;109(10):2665-74
pubmed: 24136146
Nat Rev Cancer. 2016 Jan;16(1):7-19
pubmed: 26694935
PLoS One. 2010 Jun 10;5(6):e11049
pubmed: 20548789
Gastroenterology. 2008 Jul;135(1):234-43
pubmed: 18485901
Science. 2017 Jul 28;357(6349):409-413
pubmed: 28596308
N Engl J Med. 2010 Apr 8;362(14):1273-81
pubmed: 20375404
Nat Rev Immunol. 2017 May;17(5):306-321
pubmed: 28317925
J Immunol. 2008 Feb 15;180(4):2011-7
pubmed: 18250403
Cancer Immunol Res. 2017 Dec;5(12):1109-1121
pubmed: 29097420
Nat Rev Immunol. 2019 Jun;19(6):369-382
pubmed: 30718830