Anaemia, iron homeostasis and pulmonary hypertension: a review.
Anaemia
Cardiovascular disease
Hypoxia
Iron deficiency
Pulmonary hypertension
Journal
Internal and emergency medicine
ISSN: 1970-9366
Titre abrégé: Intern Emerg Med
Pays: Italy
ID NLM: 101263418
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
28
10
2019
accepted:
28
01
2020
pubmed:
11
2
2020
medline:
11
2
2021
entrez:
11
2
2020
Statut:
ppublish
Résumé
Anaemia is a highly prevalent condition, which negatively impacts on patients' cardiovascular performance and quality of life. Anaemia is mainly caused by disturbances of iron homeostasis. While absolute iron deficiency mostly as a consequence of chronic blood loss or insufficient dietary iron absorption results in the emergence of iron deficiency anaemia, inflammation-driven iron retention in innate immune cells and blockade of iron absorption leads to the development of anaemia of chronic disease. Both, iron deficiency and anaemia have been linked to the clinical course of pulmonary hypertension. Various mechanistic links between iron homeostasis, anaemia, and pulmonary hypertension have been described and current treatment guidelines suggest regular iron status assessment and the implementation of iron supplementation strategies in these patients. The pathophysiology, diagnostic assessment as well as current and future treatment options concerning iron deficiency with or without anaemia in individuals suffering from pulmonary hypertension are discussed within this review.
Identifiants
pubmed: 32040829
doi: 10.1007/s11739-020-02288-1
pii: 10.1007/s11739-020-02288-1
pmc: PMC7289779
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
573-585Subventions
Organisme : Oesterreichische Nationalbank
ID : 17271
Pays : International
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