The Influence of Thyroid Hormones on Brain Structure and Function in Humans.


Journal

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
ISSN: 1439-3646
Titre abrégé: Exp Clin Endocrinol Diabetes
Pays: Germany
ID NLM: 9505926

Informations de publication

Date de publication:
Jun 2020
Historique:
pubmed: 11 2 2020
medline: 23 3 2021
entrez: 11 2 2020
Statut: ppublish

Résumé

The pleiotropic function of thyroid hormones (TH) is mediated by an organ specific expression of thyroid hormone transporters, deiodinases and TH receptors. In a series of studies we used the model of an experimentally induced hyper- or hypothyroidism in human volunteers to delineate TH action on the brain. A battery of neuropsychological testing paradigms was employed and complemented by structural and functional multimodal neuroimaging. Experimentally induced mild thyrotoxicosis for 6 weeks was associated with changes in brain structure (determined with voxel-based morphometry), resting state functional connectivity, and task-related functional activation in a working memory paradigm. Partial withdrawal of TH replacement in patients without thyroid (subclinical hypothyroidism) likewise lead to changes on multiple functional and structural brain measures. Importantly, the series of studies reviewed here identified the cerebellum as one crucial site of action.

Identifiants

pubmed: 32040963
doi: 10.1055/a-1101-9090
doi:

Substances chimiques

Thyroid Hormones 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

432-436

Subventions

Organisme : DFG MU1311/16-2
ID : TFM, AS and GB

Informations de copyright

© Georg Thieme Verlag KG Stuttgart · New York.

Déclaration de conflit d'intérêts

The authors declare that they have no conflict of interest.

Auteurs

Anna Göbel (A)

Department of Neurology, University of Lübeck, Lübeck, Germany.

Martin Göttlich (M)

Department of Neurology, University of Lübeck, Lübeck, Germany.

Jonathan Reinwald (J)

Central Institute of Mental Health, Mannheim, Germany.

Berenike Rogge (B)

Department of Neurology, University of Lübeck, Lübeck, Germany.

Jan-Christoph Uter (JC)

Department of Neurology, University of Lübeck, Lübeck, Germany.

Marcus Heldmann (M)

Department of Neurology, University of Lübeck, Lübeck, Germany.
Department of Psychology II, University of Lübeck, Lübeck, Germany.

Alexander Sartorius (A)

Central Institute of Mental Health, Mannheim, Germany.

Georg Brabant (G)

Department of Internal Medicine I, University of Lübeck, Lübeck, Germany.

Thomas F Münte (TF)

Department of Neurology, University of Lübeck, Lübeck, Germany.
Department of Psychology II, University of Lübeck, Lübeck, Germany.

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Classifications MeSH