Amyloid-Beta
Alzheimer Disease
/ metabolism
Amyloid beta-Peptides
/ metabolism
Animals
CA1 Region, Hippocampal
/ metabolism
Hippocampus
/ metabolism
Male
Memory
/ physiology
Mice
Mice, Inbred C57BL
Pyramidal Cells
/ metabolism
Receptors, GABA-A
/ metabolism
Synapses
/ metabolism
Synaptic Transmission
/ physiology
gamma-Aminobutyric Acid
/ metabolism
GABA 1
GABAA receptor 2
amyloid-beta 4
hippocampus 5
tonic inhibition 3
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Feb 2020
06 Feb 2020
Historique:
received:
28
11
2019
revised:
03
02
2020
accepted:
03
02
2020
entrez:
12
2
2020
pubmed:
12
2
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a complex and chronic neurodegenerative disorder that involves a progressive and severe decline in cognition and memory. During the last few decades a considerable amount of research has been done in order to better understand tau-pathology, inflammatory activity and neuronal synapse loss in AD, all of them contributing to cognitive decline. Early hippocampal network dysfunction is one of the main factors associated with cognitive decline in AD. Much has been published about amyloid-beta
Identifiants
pubmed: 32041202
pii: molecules25030693
doi: 10.3390/molecules25030693
pmc: PMC7037727
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Receptors, GABA-A
0
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Freemasons New Zeland
ID : 3719321
Organisme : Alzheimers New Zealand
ID : 3718869
Organisme : Alzheimers New Zealand Charitable Trust
ID : 502575
Organisme : Aotearoa Foundation, Centre for Brain Research, University of Auckland
ID : 3705579
Organisme : Brain Research New Zealand
ID : 3710638
Organisme : Health Research Council of New Zealand
ID : 3627373
Références
Nat Neurosci. 2003 May;6(5):484-90
pubmed: 12679782
J Alzheimers Dis Parkinsonism. 2018;8(1):
pubmed: 29928558
J Neurochem. 2018 Sep;146(6):649-669
pubmed: 29645219
Front Neurosci. 2019 Nov 07;13:1154
pubmed: 31787864
Front Neurosci. 2020 Jan 17;13:1427
pubmed: 32009891
Neuroscience. 2000;96(4):657-64
pubmed: 10727784
J Neurochem. 2008 Jul;106(1):392-404
pubmed: 18397369
Anesthesiology. 2009 Nov;111(5):1025-35
pubmed: 19809285
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8980-5
pubmed: 12084936
J Neurochem. 2018 Jun;145(5):374-392
pubmed: 29485232
Neurology. 1999 May 12;52(8):1687-9
pubmed: 10331700
Future Med Chem. 2011 Feb;3(2):149-53
pubmed: 21428809
FASEB J. 2004 Mar;18(3):511-8
pubmed: 15003996
eNeuro. 2019 Aug 14;6(4):
pubmed: 31340951
Front Aging Neurosci. 2016 Feb 23;8:31
pubmed: 26941642
Nat Rev Neurosci. 2007 Jan;8(1):45-56
pubmed: 17180162
Brain Res Bull. 1998;45(4):341-79
pubmed: 9527011
Front Neurosci. 2019 Jun 21;13:659
pubmed: 31293377
Mol Neurodegener. 2015 Dec 02;10:65
pubmed: 26628003
Sci Rep. 2016 Feb 16;6:21101
pubmed: 26879842
Curr Mol Med. 2015;15(2):146-67
pubmed: 25732149
Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):E2895-903
pubmed: 22869752
Sci Rep. 2018 Jan 10;8(1):302
pubmed: 29321592
J Psychiatry Neurosci. 2013 Jan;38(1):6-23
pubmed: 22894822
Curr Alzheimer Res. 2011 Mar;8(2):203-12
pubmed: 21222604
Neuroscience. 2017 May 20;351:108-118
pubmed: 28385633
Int J Mol Sci. 2017 Aug 21;18(8):
pubmed: 28825683
J Neurosci. 2002 Jul 1;22(13):5572-80
pubmed: 12097508
Neural Regen Res. 2018 Aug;13(8):1362-1363
pubmed: 30106045
Front Neural Circuits. 2014 Feb 03;8:3
pubmed: 24550784
Trends Neurosci. 2007 Jul;30(7):343-9
pubmed: 17532059
J Neurophysiol. 2006 May;95(5):2796-807
pubmed: 16452257
Nat Commun. 2014 Jun 13;5:4159
pubmed: 24923909
Nature. 2009 Feb 26;457(7233):1128-32
pubmed: 19242475
Brain Res. 1998 Jun 15;796(1-2):239-46
pubmed: 9689474
Hippocampus. 2001;11(6):655-61
pubmed: 11811659
Nature. 2012 Sep 6;489(7414):150-4
pubmed: 22842902
Nat Med. 2014 Aug;20(8):886-96
pubmed: 24973918