Genotype-independent association between vitamin D deficiency and polycystic ovarian syndrome in Lahore, Pakistan.
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
/ genetics
Adult
Age Factors
Body Mass Index
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Pakistan
/ epidemiology
Polycystic Ovary Syndrome
/ blood
Polymorphism, Single Nucleotide
Receptors, Calcitriol
/ genetics
Risk Assessment
Risk Factors
Vitamin D
/ analogs & derivatives
Vitamin D Deficiency
/ blood
Vitamin D-Binding Protein
/ genetics
Vitamin D3 24-Hydroxylase
/ genetics
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 02 2020
10 02 2020
Historique:
received:
17
07
2019
accepted:
27
01
2020
entrez:
12
2
2020
pubmed:
12
2
2020
medline:
21
11
2020
Statut:
epublish
Résumé
Both vitamin D deficiency and single nucleotide polymorphisms (SNPs) in the gene encoding the vitamin D receptor (VDR) have been widely reported to associate with susceptibility to polycystic ovarian syndrome (PCOS). A case-control study was conducted to study the influence of vitamin D status and genotpye for 24 SNPs in four genes in the vitamin D pathway (VDR, DBP, CYP27B1, CYP24A1) on PCOS. Statistical analyses were conducted to identify phenotypic and genotypic factors associated with risk of PCOS and to test for interactions between genotype and vitamin D status. PCOS was independently associated with lower age, higher body mass index, lower waist-hip ratio, vitamin D deficiency (serum 25-hydroxyvitamin D concentration <10 ng/mL), lack of outdoor exercise, increased fasting glucose and a family history of PCOS in at least one first degree relative. No statistically significant association was observed between the genotype of any SNP investigated and risk of PCOS, either as a main effect or in interaction with vitamin D status. We report a strong and independent association between vitamin D deficiency and risk of PCOS in Pakistan, that was not modified by genetic variation in the vitamin D pathway.
Identifiants
pubmed: 32042037
doi: 10.1038/s41598-020-59228-4
pii: 10.1038/s41598-020-59228-4
pmc: PMC7010676
doi:
Substances chimiques
GC protein, human
0
Receptors, Calcitriol
0
VDR protein, human
0
Vitamin D-Binding Protein
0
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
CYP24A1 protein, human
EC 1.14.15.16
Vitamin D3 24-Hydroxylase
EC 1.14.15.16
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
EC 1.14.15.18
CYP27B1 protein, human
EC 1.14.15.18
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2290Références
Sirmans, S. M. & Pate, K. A. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin. Epidemiol. 6, 1–13 (2013).
doi: 10.2147/CLEP.S37559
Niu, Y.-M. et al. Association Between Vitamin D Receptor Gene Polymorphisms and Polycystic Ovary Syndrome Risk: A Meta-Analysis. Front. Physiol. 9, 1–13 (2019).
Baqai, Z., Khanam, M. & Parveen, S. Prevalence of PCOS in fertile patients. Med. Channel 16, 437–440 (2010).
Rodin, D. A., Bano, G., Bland, J. M., Taylor, K. & Nussey, S. S. Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women. Clin. Endocrinol. 49, 91–99 (1998).
doi: 10.1046/j.1365-2265.1998.00492.x
Diamanti-Kandarakis, E., Kandarakis, H. & Legro, R. S. The role of genes and environment in the etiology of PCOS. Endocr. 30, 19–26 (2006).
doi: 10.1385/ENDO:30:1:19
Shi, X.-Y., Huang, A.-P., Xie, D.-W. & Yu, X.-L. Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis. BMC Med. Genet. 20, 1–11 (2019).
Reis, G. V. O. Pd et al. Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic review. J. Obstet. Gynaecol. Res. 43, 436–446 (2017).
doi: 10.1111/jog.13250
Chen, Y. & Fang, S.-Y. Potential genetic polymorphisms predicting polycystic ovary syndrome. Endocr. Connect. 7, R187–R195 (2018).
doi: 10.1530/EC-18-0121
He, C., Lin, Z., Robb, S. & Ezeamama, A. Serum vitamin D levels and polycystic ovary syndrome: a systematic review and meta-analysis. Nutrients 7, 4555–4577 (2015).
doi: 10.3390/nu7064555
Krul-Poel, Y. H. M. et al. Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study. PLoS one 13, 1–13 (2018).
doi: 10.1371/journal.pone.0204748
Krul-Poel, Y. H. M. et al. The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review. Eur. J. Endocrinol. 169, 853–865 (2013).
doi: 10.1530/EJE-13-0617
Martineau, A. R. et al. High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet 377, 242–250 (2011).
doi: 10.1016/S0140-6736(10)61889-2
Ganmaa, D. et al. High-Dose Vitamin D(3) during Tuberculosis Treatment in Mongolia. A Randomized Controlled Trial. Am. J. Respir. Crit. Care Med. 196, 628–637 (2017).
doi: 10.1164/rccm.201705-0936OC
Martineau, A. R. et al. Association between Gc genotype and susceptibility to TB is dependent on vitamin D status. Eur. Respir. J. 35, 1106–1112 (2010).
doi: 10.1183/09031936.00087009
Clark, A. G. Inference of haplotypes from PCR-amplified samples of diploid populations. Mol. Biol. Evol. 7, 111–122 (1990).
pubmed: 2108305
Mazloomi, S., Sharifi, F., Hajihosseini, R., Kalantari, S. & Mazloomzadeh, S. Association between Hypoadiponectinemia and Low Serum Concentrations of Calcium and Vitamin D in Women with Polycystic Ovary Syndrome. ISRN Endocrinol. 2012, 1–6 (2012).
doi: 10.5402/2012/949427
Hassan, N. E., El-Orabi, H. A., Eid, Y. M. & Mohammed, N. R. Effect of 25-hydroxyvitamin D on metabolic parameters and insulin resistance in patients with polycystic ovarian syndrome. Middle East. Fertil. Soc. J. 17, 176–180 (2012).
doi: 10.1016/j.mefs.2012.04.005
Nestler, J. E., Reilly, E. R., Cheang, K. I., Bachmann, L. M. & Downs, R. W. Jr. A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome. Trans. Am. Clin. Climatol. Assoc. 123, 209–220 (2012).
pubmed: 23303986
pmcid: 3540606
Bacopoulou, F., Kolias, E., Efthymiou, V., Antonopoulos, C. N. & Charmandari, E. Vitamin D predictors in polycystic ovary syndrome: a meta-analysis. Eur. J. Clin. Invest. 47, 746–755 (2017).
doi: 10.1111/eci.12800
Junaid, K., Rehman, A., Jolliffe, D. A., Wood, K. & Martineau, A. R. High prevalence of vitamin D deficiency among women of child-bearing age in Lahore Pakistan, associating with lack of sun exposure and illiteracy. BMC Womens Health 15, 83–83 (2015).
doi: 10.1186/s12905-015-0242-x
Zakar, M. Z. et al. High-dose vitamin D3 in the treatment of severe acute malnutrition: a multicenter double-blind randomized controlled trial. Am. J. Clin. Nutr. 107, 725–733 (2018).
doi: 10.1093/ajcn/nqy027
Roth, D. E. et al. Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low- and middle-income countries. Ann. N. Y. Acad. Sci. 1430, 44–79 (2018).
doi: 10.1111/nyas.13968
Sedighi, S. et al. Comparison of lifestyle in women with polycystic ovary syndrome and healthy women. Glob. J. Health Sci. 7, 228–234 (2014).
doi: 10.5539/gjhs.v7n1p228
Legro, R. S., Dodson, W. C., Kunselman, A. R. & Dunaif, A. Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women1. J. Clin. Endocrinol. Metab. 84, 165–169 (1999).
pubmed: 9920077
Azziz, R. & Kashar-Miller, M. Family history as a risk factor for the polycystic ovary syndrome. J. Pediatr. Endocrinol. Metab. 13, 1303–1306 (2000).
pubmed: 11117675
Santos, B. R., Lecke, S. B. & Spritzer, P. M. Genetic variant in vitamin D-binding protein is associated with metabolic syndrome and lower 25-hydroxyvitamin D levels in polycystic ovary syndrome: a cross-sectional study. PLoS one 12, 1–12 (2017).
Wehr, E. et al. Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome. Eur. J. Endocrinol. 164, 741–749 (2011).
doi: 10.1530/EJE-11-0134
Sachs, M. C. et al. Estimating mean annual 25-hydroxyvitamin D concentrations from single measurements: the Multi-Ethnic Study of Atherosclerosis. Am. J. Clin. Nutr. 97, 1243–1251 (2013).
doi: 10.3945/ajcn.112.054502
Group, R. E. A.-S. P. C. W. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil. Steril. 81, 19–25 (2004).
PCOS-UK-Guidelines. Diagnosis and management of polycystic ovary syndrome, https://www.guidelines.co.uk/womens-health/pcos-uk-guideline/236071.article (2012).
Khudyakov, P. et al. Prevalence and determinants of QuantiFERON-diagnosed Tuberculosis infection in 9810 Mongolian school children. Clin. Infect. Dis, 813–819 (2018).
Calman, K. Nutrition and bone health: with particular reference to calcium and vitamin D. Rep Health Soc Subj (Lond), 1-24 (1998).
Martineau, A. R. et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 356, 1–14 (2017).
Jolliffe, D. A. et al. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. Lancet Respir. Med. 5, 881–890 (2017).
doi: 10.1016/S2213-2600(17)30306-5
Jolliffe, D. A. et al. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax 74, 337–345 (2019).
doi: 10.1136/thoraxjnl-2018-212092
Martineau, A. R. Old wine in new bottles: vitamin D in the treatment and prevention of tuberculosis. Proc. Nutr. Soc. 71, 84–89 (2012).
doi: 10.1017/S0029665111003326
Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B Stat Methodol. 57, 289–300 (1995).
Hanif, F., Naveed, A. K., Rahim, A. & Waqar, F. Vitamin D level in unmarried females with Polycystic ovarian syndrome. Biochem. 2, 4 (2015).