The genetic history of France.
Journal
European journal of human genetics : EJHG
ISSN: 1476-5438
Titre abrégé: Eur J Hum Genet
Pays: England
ID NLM: 9302235
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
23
07
2019
accepted:
28
01
2020
revised:
25
11
2019
pubmed:
12
2
2020
medline:
28
5
2021
entrez:
12
2
2020
Statut:
ppublish
Résumé
The study of the genetic structure of different countries within Europe has provided significant insights into their demographic history and population structure. Although France occupies a particular location at the western part of Europe and at the crossroads of migration routes, few population genetic studies have been conducted so far with genome-wide data. In this study, we analyzed SNP-chip genetic data from 2184 individuals born in France who were enrolled in two independent population cohorts. Using FineSTRUCTURE, six different genetic clusters of individuals were found that were very consistent between the two cohorts. These clusters correspond closely to geographic, historical, and linguistic divisions of France, and contain different proportions of ancestry from Stone and Bronze Age populations. By modeling the relationship between genetics and geography using EEMS, we were able to detect gene flow barriers that are similar across the two cohorts and correspond to major rivers and mountain ranges. Estimations of effective population sizes also revealed very similar patterns in both cohorts with a rapid increase of effective population sizes over the last 150 generations similar to other European countries. A marked bottleneck is also consistently seen in the two datasets starting in the 14
Identifiants
pubmed: 32042083
doi: 10.1038/s41431-020-0584-1
pii: 10.1038/s41431-020-0584-1
pmc: PMC7316781
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
853-865Subventions
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-16-CE12-0033
Pays : International
Commentaires et corrections
Type : ErratumIn
Type : CommentIn
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