Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories.
Journal
Nature reviews. Neuroscience
ISSN: 1471-0048
Titre abrégé: Nat Rev Neurosci
Pays: England
ID NLM: 100962781
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
accepted:
18
12
2019
pubmed:
12
2
2020
medline:
7
5
2020
entrez:
12
2
2020
Statut:
ppublish
Résumé
The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating that the rest of the hippocampus (CA1-CA3) can operate autonomously under certain conditions. An extensive body of theoretical work has proposed how the architectural elements and various cell types of the DG may underlie its function in cognition. Recent studies recorded and manipulated the activity of different neuron types in the DG during memory tasks and have provided exciting new insights into the mechanisms of DG computational processes, particularly for the encoding, retrieval and discrimination of similar memories. Here, we review these DG-dependent mnemonic functions in light of the new findings and explore mechanistic links between the cellular and network properties of, and the computations performed by, the DG.
Identifiants
pubmed: 32042144
doi: 10.1038/s41583-019-0260-z
pii: 10.1038/s41583-019-0260-z
pmc: PMC7115869
mid: EMS86703
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
153-168Subventions
Organisme : European Research Council
ID : 787450
Pays : International
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