Confocal Shear Wave Acoustic Radiation Force Optical Coherence Elastography for Imaging and Quantification of the In Vivo Posterior Eye.
ARF
OCT
in-vivo study
retina
shear wave elastography
Journal
IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society
ISSN: 1077-260X
Titre abrégé: IEEE J Sel Top Quantum Electron
Pays: United States
ID NLM: 101212349
Informations de publication
Date de publication:
Historique:
entrez:
12
2
2020
pubmed:
12
2
2020
medline:
12
2
2020
Statut:
ppublish
Résumé
Retinal diseases, such as age-related macular degeneration (AMD), are the leading cause of blindness in the elderly population. Since no known cures are currently present, it is crucial to diagnose the condition in its early stages so that disease progression is monitored. Recent advances show that the mechanical elasticity of the posterior eye changes with the onset of AMD. In this work, we present a quantitative method of mapping the mechanical elasticity of the posterior eye using confocal shear wave acoustic radiation force optical coherence elastography (SW-ARF-OCE). This technique has been developed and validated with both an ex-vivo porcine tissue model and a customized in-vivo rabbit model, which both showed the quantified elasticity variations between different layers. This study verifies the feasibility of using this technology for the quantification and diagnosis of retinal diseases from the in-vivo posterior eye.
Identifiants
pubmed: 32042240
doi: 10.1109/jstqe.2018.2834435
pmc: PMC7008613
mid: NIHMS975323
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB015890
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127271
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125084
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY021529
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026091
Pays : United States
Organisme : NEI NIH HHS
ID : F31 EY027666
Pays : United States
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