A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds.
Alginate
Diabetes mellitus
Eudragit
Microencapsulation
Oral delivery
Probucol
Journal
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
ISSN: 1319-0164
Titre abrégé: Saudi Pharm J
Pays: Saudi Arabia
ID NLM: 9705695
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
27
03
2019
accepted:
29
11
2019
entrez:
12
2
2020
pubmed:
12
2
2020
medline:
12
2
2020
Statut:
ppublish
Résumé
Bile acids (BAs) are amphiphilic compounds and of recently have demonstrated wide range of formulation stabilizing effects. A recent study showed that primary un-metabolised bile acids (PUBAs) have β-cell protective effects, and synergistic antidiabetic effects when combined with antioxidant and anti-inflammatory drugs, such as probucol (PB). Thus, this study aimed to design and test microcapsules containing a PUBA incorporated with PB and an alginate-Eudragit matrix. Six types of microcapsules were developed without (control) or with (test) PUBA, and tested for internal and external features and β-cell protective effects. The incorporation of PB-alginate-Eudragit with PUBA produced stable microcapsules but did not exert consistent positive effects on cell viability in the hyperglycaemic state, which suggests that PUBA in alginate-Eudragit matrices did not exhibit synergistic effects with PB nor exerted antidiabetic effects.
Identifiants
pubmed: 32042255
doi: 10.1016/j.jsps.2019.11.017
pii: S1319-0164(19)30168-9
pmc: PMC7000308
doi:
Types de publication
Journal Article
Langues
eng
Pagination
165-171Informations de copyright
© 2019 Published by Elsevier B.V. on behalf of King Saud University.
Déclaration de conflit d'intérêts
Al-Salami H has been and is currently receiving funding from Beijing Nat-Med Biotechnology Co. Ltd.
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