Hypothalamic lipoma and growth hormone deficiency.
Child
Growth hormone deficiency
Hypothalamic lipoma
Intracranial lipoma
Journal
International journal of pediatric endocrinology
ISSN: 1687-9848
Titre abrégé: Int J Pediatr Endocrinol
Pays: England
ID NLM: 101516111
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
11
2019
accepted:
27
01
2020
entrez:
12
2
2020
pubmed:
12
2
2020
medline:
12
2
2020
Statut:
ppublish
Résumé
Intracranial lipomas are rare, congenital lesions, most often located at the midline. Most hypothalamic lipomas are asymptomatic, but some cases have been associated with precocious puberty, hypothermia, headache and/or obesity. A 7-year-old boy was referred for short stature and proved to be partially growth-hormone deficient. Magnetic resonance imaging (MRI) revealed a lipoma in the paramedian hypothalamus. Growth hormone treatment resulted in swift and uncomplicated catch-up growth. The present case appears to be the first to link hypothalamic lipoma to GH deficiency. The neuro-endocrine pathophysiology underpinning this link remains to be explored.
Sections du résumé
BACKGROUND
BACKGROUND
Intracranial lipomas are rare, congenital lesions, most often located at the midline. Most hypothalamic lipomas are asymptomatic, but some cases have been associated with precocious puberty, hypothermia, headache and/or obesity.
CASE PRESENTATION
METHODS
A 7-year-old boy was referred for short stature and proved to be partially growth-hormone deficient. Magnetic resonance imaging (MRI) revealed a lipoma in the paramedian hypothalamus. Growth hormone treatment resulted in swift and uncomplicated catch-up growth.
CONCLUSIONS
CONCLUSIONS
The present case appears to be the first to link hypothalamic lipoma to GH deficiency. The neuro-endocrine pathophysiology underpinning this link remains to be explored.
Identifiants
pubmed: 32042280
doi: 10.1186/s13633-020-0074-9
pii: 74
pmc: PMC7001293
doi:
Types de publication
Case Reports
Langues
eng
Pagination
4Informations de copyright
© The Author(s). 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
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