Aligned chitosan nanofiber hydrogel grafted with peptides mimicking bioactive brain-derived neurotrophic factor and vascular endothelial growth factor repair long-distance sciatic nerve defects in rats.
Animals
Brain-Derived Neurotrophic Factor
/ metabolism
Chitosan
/ chemistry
Hydrogels
/ chemistry
Nanofibers
/ chemistry
Nerve Regeneration
/ drug effects
Nerve Tissue
/ transplantation
Peptides
/ metabolism
Peripheral Nerve Injuries
Rats
Recovery of Function
/ drug effects
Schwann Cells
/ drug effects
Sciatic Nerve
/ drug effects
Stress, Mechanical
Vascular Endothelial Growth Factor A
/ metabolism
Peripheral nerve injury
chitosan nanofibers
electrospinning
mechanical stretching
peptides.
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
05
2019
accepted:
12
08
2019
entrez:
12
2
2020
pubmed:
12
2
2020
medline:
14
4
2021
Statut:
epublish
Résumé
Autologous nerve transplantation, which is the gold standard for clinical treatment of peripheral nerve injury, still has many limitations. In this study, aligned chitosan fiber hydrogel (ACG) grafted with a bioactive peptide mixture consisting of RGI (Ac-RGIDKRHWNSQGG) and KLT (Ac-KLTWQELYQLKYKGIGG), designated as ACG-RGI/KLT, was used as nerve conduit filler to repair sciatic nerve defects in rats.
Identifiants
pubmed: 32042324
doi: 10.7150/thno.36272
pii: thnov10p1590
pmc: PMC6993237
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Hydrogels
0
Peptides
0
Vascular Endothelial Growth Factor A
0
BDNF protein, human
7171WSG8A2
Chitosan
9012-76-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1590-1603Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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