Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in
In-silico Saturation Mutagenesis
Mutation Coolspots
Mycobacterium leprae
RNA Polymerase
Rifampin
Thermodynamic stability
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
07
2019
revised:
03
01
2020
accepted:
07
01
2020
entrez:
12
2
2020
pubmed:
12
2
2020
medline:
12
2
2020
Statut:
epublish
Résumé
Rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic tools. A quick and reliable method is essential to determine the impacts of emerging detrimental mutations in the drug targets. The functional consequences of missense mutations in the β-subunit of RNA polymerase (RNAP) in The emergence of primary and secondary drug resistance to rifampin in leprosy is a growing concern and poses a threat to the leprosy control and elimination measures globally. In the absence of an effective
Identifiants
pubmed: 32042379
doi: 10.1016/j.csbj.2020.01.002
pii: S2001-0370(19)30291-0
pmc: PMC7000446
doi:
Types de publication
Journal Article
Langues
eng
Pagination
271-286Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M026302/1
Pays : United Kingdom
Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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