Indices calculated by serum creatinine and cystatin C as predictors of liver damage, muscle strength and sarcopenia in liver disease.
creatinine
cystatin C
estimated glomerular filtration rate
liver function
muscle strength
Journal
Biomedical reports
ISSN: 2049-9434
Titre abrégé: Biomed Rep
Pays: England
ID NLM: 101613227
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
14
06
2019
accepted:
28
10
2019
entrez:
12
2
2020
pubmed:
12
2
2020
medline:
12
2
2020
Statut:
ppublish
Résumé
Serum creatinine (Cr)-based glomerular filtration rate (CrGFR) is overestimated in liver disease. The present study evaluated whether the difference in CrGFR and cystatin C (CysC) GFR (dGFR) is significant in liver disease. The Cr-to-CysC ratio and sarcopenia index (SI) have been reported to correlate with muscle volume. An estimated total body muscle mass with Cr, CysC and calculated body muscle mass (CBMM) has also been reported to correlate with muscle mass. The applicability of dGFR, SI and CBMM for liver disease were evaluated. A total of 313 patients with liver damage were evaluated for Child-Pugh score, albumin-bilirubin (ALBI) score, model for end-stage liver disease, fibrosis-4, Cr, CysC, Cr-based estimated GFR (CreGFR), CysCGFR and grip strength. Of the 313 patients, 199 were evaluated using cross-sectional computed tomography (CT) of the third lumbar vertebra to determine the skeletal muscle (SM) mass. dGFR, CBMM and SI were compared to liver damage, muscle strength and muscle mass. In the 313 patients, dGFR was correlated with age, ALBI and grip strength; CBMM was correlated with body mass index (BMI) and grip strength; and SI was correlated with BMI and grip strength. In patients evaluated with CT, the correlation coefficients for CBMM and SI with SM were 0.804 and 0.293, respectively. Thus, CBMM and SI were associated with sarcopenia. The relationship between dGFR and ALBI does not differ with different grades of CrGFR-based chronic kidney disease (CKD). dGFR is a marker of liver damage and muscle strength regardless of CKD. CBMM and SI are markers for sarcopenia in liver disease.
Identifiants
pubmed: 32042417
doi: 10.3892/br.2020.1273
pii: BR-0-0-1273
pmc: PMC7006091
doi:
Types de publication
Journal Article
Langues
eng
Pagination
89-98Informations de copyright
Copyright © 2019, Spandidos Publications.
Références
Am J Kidney Dis. 2013 Sep;62(3):595-603
pubmed: 23701892
Eur J Gastroenterol Hepatol. 2001 Aug;13(8):951-5
pubmed: 11507361
J Hepatol. 2016 Oct;65(4):809-824
pubmed: 27238754
J Clin Oncol. 2015 Feb 20;33(6):550-8
pubmed: 25512453
Major Probl Clin Surg. 1964;1:1-85
pubmed: 4950264
J Hepatol. 2018 Apr;68(4):707-714
pubmed: 29221886
Liver Transpl. 2017 Nov;23(11):1451-1464
pubmed: 29072825
Br J Surg. 1973 Aug;60(8):646-9
pubmed: 4541913
Hepatol Res. 2019 Feb;49(2):153-163
pubmed: 30005446
Hepatol Res. 2016 Sep;46(10):951-63
pubmed: 27481650
PLoS One. 2018 Aug 1;13(8):e0200061
pubmed: 30067754
Liver Transpl. 2017 Feb;23(2):143-154
pubmed: 28061014
Am J Kidney Dis. 2003 Feb;41(2):269-78
pubmed: 12552488
Hepatology. 2001 Feb;33(2):464-70
pubmed: 11172350
J Hepatol. 2019 May;70(5):847-854
pubmed: 30630010
PLoS One. 2018 Dec 12;13(12):e0208903
pubmed: 30540824
Medicine (Baltimore). 2017 May;96(20):e6949
pubmed: 28514315
PLoS One. 2016 Feb 05;11(2):e0148495
pubmed: 26849842
Diabetes Res Clin Pract. 2018 May;139:52-58
pubmed: 29496508
J Hepatol. 2015 Jul;63(1):131-40
pubmed: 25724366
Sci Rep. 2018 Aug 1;8(1):11534
pubmed: 30068907
Hepatology. 2007 Jul;46(1):32-6
pubmed: 17567829
Aliment Pharmacol Ther. 2018 Aug;48(3):300-312
pubmed: 29920701
Clin Nutr. 2019 Jun;38(3):1362-1367
pubmed: 29921462
J Gastroenterol. 2015 Dec;50(12):1206-13
pubmed: 25820219
PLoS One. 2016 Nov 10;11(11):e0166373
pubmed: 27832209
Dig Dis Sci. 2018 Mar;63(3):665-675
pubmed: 29392554
Mol Clin Oncol. 2017 Sep;7(3):449-453
pubmed: 28781818
Clin J Am Soc Nephrol. 2014 Oct 7;9(10):1720-8
pubmed: 25074839
Curr Opin Clin Nutr Metab Care. 2010 May;13(3):271-6
pubmed: 20154609
Am J Nephrol. 2017;45(4):320-326
pubmed: 28245441
Clin J Am Soc Nephrol. 2008 Mar;3(2):348-54
pubmed: 18235143
J Cachexia Sarcopenia Muscle. 2013 Mar;4(1):19-29
pubmed: 22777757
Clin Transplant. 2018 Mar;32(3):e13182
pubmed: 29274246
Aging Male. 2017 Jun;20(2):110-114
pubmed: 27650550
J Clin Diagn Res. 2017 Apr;11(4):BC09-BC12
pubmed: 28571128
Kidney Int. 2011 Jul;80(1):17-28
pubmed: 21150873
Crit Care Med. 2017 Jan;45(1):e23-e29
pubmed: 27611976
Medicine (Baltimore). 2017 Mar;96(10):e6289
pubmed: 28272253