All-fibre supercontinuum laser for
Fibre lasers
Lipids
Photoacoustic microscopy
Supercontinuum
Journal
Photoacoustics
ISSN: 2213-5979
Titre abrégé: Photoacoustics
Pays: Germany
ID NLM: 101622604
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
16
12
2019
revised:
15
01
2020
accepted:
22
01
2020
entrez:
12
2
2020
pubmed:
12
2
2020
medline:
12
2
2020
Statut:
epublish
Résumé
Among the numerous endogenous biological molecules, information on lipids is highly coveted for understanding both aspects of developmental biology and research in fatal chronic diseases. Due to the pronounced absorption features of lipids in the extended near-infrared region (1650-1850 nm), visualisation and identification of lipids become possible using multi-spectral photoacoustic (optoacoustic) microscopy. However, the spectroscopic studies in this spectral region require lasers that can produce high pulse energies over a broad spectral bandwidth to efficiently excite strong photoacoustic signals. The most well-known laser sources capable of satisfying the multi-spectral photoacoustic microscopy requirements (tunability and pulse energy) are tunable nanosecond optical parametric oscillators. However, these lasers have an inherently large footprint, thus preventing their use in compact microscopy systems. Besides, they exhibit low-repetition rates. Here, we demonstrate a compact all-fibre, high pulse energy supercontinuum laser that covers a spectral range from 1440 to 1870 nm with a 7 ns pulse duration and total energy of 18.3 μJ at a repetition rate of 100 kHz. Using the developed high-pulse energy source, we perform multi-spectral photoacoustic microscopy imaging of lipids, both
Identifiants
pubmed: 32042589
doi: 10.1016/j.pacs.2020.100163
pii: S2213-5979(20)30003-3
pii: 100163
pmc: PMC6997905
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100163Informations de copyright
Crown Copyright © 2020 Published by Elsevier GmbH.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest
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