Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements.
B-GLAP, bone gamma-carboxyglutamate
BMMNC, bone marrow mononuclear cells
BVG, bioresorbable vascular graft
CXCL12, stromal cell-derived factor-1α (SDF1α)
ECM, extracellular matrix
IL, interleukin
MCP, monocyte chemoattractant protein
MMP, matrix metalloproteinase
PC-BU, polycarbonate bisurea
SMA, smooth muscle actin
TEE, transesophageal echocardiography
TEHV, tissue-engineered heart valve
TGF, transforming growth factor
TVR, transcatheter valve replacement
cardiovascular regenerative medicine
endogenous tissue regeneration
in situ tissue engineering
supramolecular polymer
tissue-engineered heart valve
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
13
05
2019
revised:
16
09
2019
accepted:
16
09
2019
entrez:
12
2
2020
pubmed:
12
2
2020
medline:
12
2
2020
Statut:
epublish
Résumé
This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell-scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach.
Identifiants
pubmed: 32043018
doi: 10.1016/j.jacbts.2019.09.008
pii: S2452-302X(19)30310-9
pmc: PMC7000873
doi:
Types de publication
Journal Article
Langues
eng
Pagination
15-31Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Authors.
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