Recovery training or over-training? The contribution of TLR10 to monocyte fitness.
Journal
Immunology
ISSN: 1365-2567
Titre abrégé: Immunology
Pays: England
ID NLM: 0374672
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
entrez:
12
2
2020
pubmed:
12
2
2020
medline:
30
4
2020
Statut:
ppublish
Résumé
The concept of trained immunity refers to remodelling of the monocyte and macrophage metabolic and epigenetic landscape, conferring an amplified inflammatory response upon secondary stimulation. This effect is typically modelled in vitro by stimulating monocytes with either Bacillus Calmette Guerin (BCG) or β-Glucan for 24 hr, before subsequent stimulation with LPS or Pam-3-Cys (P3C) as a secondary stimulus 6 days later. Here, we focus on a recent paper which interrogated the role of the anti-inflammatory TLR, TLR10, on trained immunity. Using both an in vitro model of trained immunity, and analysis of BCG vaccinated individuals, the authors interestingly demonstrate that, despite its ability to regulate aspects of innate immunity, TLR10 does not have a significant role in this process.
Identifiants
pubmed: 32043595
doi: 10.1111/imm.13177
pmc: PMC7011651
doi:
Substances chimiques
TLR10 protein, human
0
Toll-Like Receptor 10
0
Types de publication
Editorial
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
243-244Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
Science. 2014 Sep 26;345(6204):1251086
pubmed: 25258085
Science. 2014 Sep 26;345(6204):1250684
pubmed: 25258083
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17537-42
pubmed: 22988082
Clin Exp Immunol. 2015 Sep;181(3):434-40
pubmed: 25880788
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4478-84
pubmed: 25288745
Immunology. 2004 Aug;112(4):521-30
pubmed: 15270722
Immunology. 2020 Mar;159(3):289-297
pubmed: 31671203
Cell Metab. 2016 Dec 13;24(6):807-819
pubmed: 27866838
Cell Metab. 2019 Jan 8;29(1):211-220.e5
pubmed: 30293776