Exercise training improves radiotherapy efficiency in a murine model of prostate cancer.
Animals
Antigens, Ly
/ genetics
Apoptosis
Caspase 3
/ genetics
Cell Line, Tumor
Combined Modality Therapy
Humans
Interleukin-2 Receptor beta Subunit
/ genetics
Male
Mice
NK Cell Lectin-Like Receptor Subfamily B
/ genetics
NK Cell Lectin-Like Receptor Subfamily K
/ genetics
Physical Conditioning, Animal
/ methods
Prostatic Neoplasms
/ metabolism
Radiotherapy
/ methods
oncology
physical activity
radiation therapy
treatment
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
16
07
2019
revised:
23
12
2019
accepted:
22
01
2020
pubmed:
12
2
2020
medline:
20
1
2021
entrez:
12
2
2020
Statut:
ppublish
Résumé
Engaging in exercise while undergoing radiotherapy (RT) has been reported to be safe and achievable. The impact of exercise training (ET) on RT efficiency is however largely unknown. Our study aims to investigate the interactions between ET and RT on prostate cancer growth. Athymic mice received a subcutaneous injection of PPC-1 cells and were randomly assigned to either cancer control, cancer ET, cancer RT, or cancer RT combined with ET (CaRT-ET). Mice were sacrificed 24 days post-injection. All three intervention groups had reduced tumor size, the most important decrease being observed in CaRT-ET mice. Apoptotic marker cleaved caspase-3 was not modified by ET, but enhanced with RT. Importantly, this increase was the highest when the two strategies were combined. Furthermore, NK1.1 staining and gene expression of natural killer (NK) cell receptors Klrk1 and Il2rβ were not affected by ET alone but were increased with RT, this effect being potentiated when combined with ET. Overall, our study shows that (a) ET enhances RT efficiency by potentiating NK cell infiltration, and (b) while ET alone and ET combined with RT both reduce tumor growth, the mechanisms mediating these effects are different.
Identifiants
pubmed: 32043634
doi: 10.1096/fj.201901728R
doi:
Substances chimiques
Antigens, Ly
0
Il2rb protein, mouse
0
Interleukin-2 Receptor beta Subunit
0
Klrb1c protein, mouse
0
Klrk1 protein, mouse
0
NK Cell Lectin-Like Receptor Subfamily B
0
NK Cell Lectin-Like Receptor Subfamily K
0
Caspase 3
EC 3.4.22.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4984-4996Informations de copyright
© 2020 Federation of American Societies for Experimental Biology.
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