Soft tissue deposit in neck dissection specimen carries a poor prognosis in oral cancer: A matched pair analysis.
STD
neck dissection
oral cancer
soft tissue deposit
tumor deposit
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
02
06
2019
revised:
06
12
2019
accepted:
28
01
2020
pubmed:
12
2
2020
medline:
22
6
2021
entrez:
12
2
2020
Statut:
ppublish
Résumé
Soft tissue deposit (STD) is the presence of tumor foci in the neck at sites other than lymphoid tissue. We evaluated the factors associated with STD and their impact on outcomes. The records of 4812 treatment naïve oral cancers operated between December 2010 and September 2015 were screened for the presence of STD. A matched-pair analysis was performed to obtain 450 patients without STD. Chi-square was used to test association with clinicopathological factors and hazard ratio (HR) for overall survival (OS) and disease-free survival (DFS) were calculated. STD was present in 0.6% and associated with gingiva-buccal cancers, advanced stage, poor differentiation, presence of extranodal extension (ENE) and higher locoregional/distant metastasis. They had a significantly poorer OS (HR-2.08; P-value .0073) and DFS (HR-2.5; P-value .0002) with and without ENE [HR-1.96 and 3.7, respectively]. Despite aggressive adjuvant therapy STD has a significant negative impact on outcomes.
Sections du résumé
BACKGROUND
Soft tissue deposit (STD) is the presence of tumor foci in the neck at sites other than lymphoid tissue. We evaluated the factors associated with STD and their impact on outcomes.
METHODS
The records of 4812 treatment naïve oral cancers operated between December 2010 and September 2015 were screened for the presence of STD. A matched-pair analysis was performed to obtain 450 patients without STD. Chi-square was used to test association with clinicopathological factors and hazard ratio (HR) for overall survival (OS) and disease-free survival (DFS) were calculated.
RESULTS
STD was present in 0.6% and associated with gingiva-buccal cancers, advanced stage, poor differentiation, presence of extranodal extension (ENE) and higher locoregional/distant metastasis. They had a significantly poorer OS (HR-2.08; P-value .0073) and DFS (HR-2.5; P-value .0002) with and without ENE [HR-1.96 and 3.7, respectively].
CONCLUSION
Despite aggressive adjuvant therapy STD has a significant negative impact on outcomes.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1783-1790Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 Wiley Periodicals, Inc.
Références
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