Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning.


Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
03 2020
Historique:
received: 06 09 2019
revised: 21 10 2019
accepted: 25 11 2019
pubmed: 12 2 2020
medline: 27 11 2020
entrez: 12 2 2020
Statut: ppublish

Résumé

Developing cross-validated multi-biomarker models for the prediction of the rate of cognitive decline in Alzheimer's disease (AD) is a critical yet unmet clinical challenge. We applied support vector regression to AD biomarkers derived from cerebrospinal fluid, structural magnetic resonance imaging (MRI), amyloid-PET and fluorodeoxyglucose positron-emission tomography (FDG-PET) to predict rates of cognitive decline. Prediction models were trained in autosomal-dominant Alzheimer's disease (ADAD, n = 121) and subsequently cross-validated in sporadic prodromal AD (n = 216). The sample size needed to detect treatment effects when using model-based risk enrichment was estimated. A model combining all biomarker modalities and established in ADAD predicted the 4-year rate of decline in global cognition (R Our independently validated machine-learning model predicted cognitive decline in sporadic prodromal AD and may substantially reduce sample size needed in clinical trials in AD.

Identifiants

pubmed: 32043733
doi: 10.1002/alz.12032
pmc: PMC7222030
mid: NIHMS1565951
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

501-511

Subventions

Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG053474
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : UF1 AG032438
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG032438
Pays : United States

Informations de copyright

© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.

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Auteurs

Nicolai Franzmeier (N)

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.

Nikolaos Koutsouleris (N)

Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität LMU, Munich, Germany.

Tammie Benzinger (T)

Department of Radiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.

Alison Goate (A)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Celeste M Karch (CM)

Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.
Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, Missouri, USA.
Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri, USA.

Anne M Fagan (AM)

Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.
Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, Missouri, USA.
Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.

Eric McDade (E)

Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.
Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.

Marco Duering (M)

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.

Martin Dichgans (M)

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.
Munich Cluster for Systems Neurology, Munich, Germany.
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

Johannes Levin (J)

Munich Cluster for Systems Neurology, Munich, Germany.
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.

Brian A Gordon (BA)

Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.
Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA.
Department of Psychological and Brain Sciences, Washington University, St. Louis, Missouri, USA.

Yen Ying Lim (YY)

The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia.

Colin L Masters (CL)

The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia.

Martin Rossor (M)

Dementia Research Centre, University College London, Queen Square, London, UK.

Nick C Fox (NC)

Dementia Research Centre, University College London, Queen Square, London, UK.

Antoinette O'Connor (A)

Dementia Research Centre, University College London, Queen Square, London, UK.

Jasmeer Chhatwal (J)

Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA.

Stephen Salloway (S)

Department of Neurology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Adrian Danek (A)

Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.

Jason Hassenstab (J)

Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.
Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
Department of Psychological and Brain Sciences, Washington University, St. Louis, Missouri, USA.

Peter R Schofield (PR)

Neuroscience Research Australia, Randwick, New South Wales, Australia.
School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.

John C Morris (JC)

Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.
Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri, USA.
Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.

Randall J Bateman (RJ)

Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.
Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
ADNI Consortium members are listed in the appendix.
DIAN Consortium members are listed in the appendix.

Michael Ewers (M)

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.

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