Current understanding of human herpesvirus 6 (HHV-6) chromosomal integration.
Germ line
Human herpesvirus 6
Integration
Telomeres
iciHHV-6
Journal
Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
17
12
2019
revised:
21
01
2020
accepted:
23
01
2020
pubmed:
12
2
2020
medline:
12
1
2021
entrez:
12
2
2020
Statut:
ppublish
Résumé
Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are members of the genus Roseolovirus in the Betaherpesvirinae subfamily. HHV-6B infects humans in the first years of life, has a seroprevalence of more than 90% and causes Roseola Infantum, but less is known about HHV-6A. While most other herpesviruses maintain their latent genome as a circular episome, HHV-6A and HHV-6B (HHV-6A/B) have been shown to integrate their genome into the telomeres of infected cells. HHV-6A/B can also integrate into the chromosomes of germ cells, resulting in individuals carrying a copy of the virus genome in every nucleated cell of their bodies. This review highlights our current understanding of HHV-6A/B integration and reactivation as well as aspects that should be addressed in the future of this relatively young research area. It forms part of an online symposium on the prevention and therapy of DNA virus infections, dedicated to the memory of Mark Prichard.
Identifiants
pubmed: 32044155
pii: S0166-3542(19)30724-7
doi: 10.1016/j.antiviral.2020.104720
pii:
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104720Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.