Elevated Serum α-Synuclein Levels in Huntington's Disease Patients.

Humans Huntington Disease Parkinson Disease alpha-Synuclein
asymptomatic HD carriers huntingtin huntington’s disease serum α-synuclein

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
01 04 2020
Historique:
received: 31 08 2019
revised: 27 01 2020
accepted: 28 01 2020
pubmed: 12 2 2020
medline: 15 5 2021
entrez: 12 2 2020
Statut: ppublish

Résumé

Recent evidence suggests a potential role for mixed proteinopathies in the development of clinical manifestations in patients with Huntington's disease (HD). A possible cross-talk between mutant huntingtin and α-synuclein aggregates has been postulated. Serum α-synuclein has been evaluated as a potential biomarker in patients with Parkinson's disease (PD). We presently sought to investigate serum α-synuclein levels in 38 HD patients (34 symptomatic and 4 premanifest) and compare them to 36 controls. We found that α-synuclein was elevated in HD patients vs. controls (2.49 ± 1.47 vs. 1.40 ± 1.16, p = 0.001). There was no difference in α-synuclein levels between symptomatic vs. premanifest HD, nor between HD patients receiving medication vs. treatment-naïve. Furthermore, α-synuclein levels showed no correlation with CAG2, Unified HD Rating Scale (UHDRS) motor score, age, disease duration or disease burden score. Our results provide evidence for elevated serum α-synuclein in HD and lend support to further investigating the role of α-synuclein in this disorder.

Identifiants

DOI: 10.1016/j.neuroscience.2020.01.037 PMID: 32045629
pubmed: 32045629
pii: S0306-4522(20)30067-1
doi: 10.1016/j.neuroscience.2020.01.037
pii:
doi:

Substances chimiques

alpha-Synuclein 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

34-39

Informations de copyright

Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

Auteurs

Marianthi Breza (M)

1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: marianthibr@med.uoa.gr.

Evangelia Emmanouilidou (E)

Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; Laboratory of Biochemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece.

Emmanouela Leandrou (E)

Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Chrisoula Kartanou (C)

1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Anastasia Bougea (A)

1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Marios Panas (M)

1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Leonidas Stefanis (L)

1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Georgia Karadima (G)

1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Kostas Vekrellis (K)

Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Georgios Koutsis (G)

1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Elevated Serum α-Synuclein Levels in...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie de Huntington › Elevated Serum α-Synuclein Levels in...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Elevated Serum α-Synuclein Levels in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › Elevated Serum α-Synuclein Levels in...