The Role Played by Wnt/β-Catenin Signaling Pathway in Acute Lymphoblastic Leukemia.
Wnt/β-catenin
acute lymphoblastic leukemia
hematopoietic stem cells
leukemic stem cells
signaling pathway
targeted therapy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Feb 2020
07 Feb 2020
Historique:
received:
20
12
2019
revised:
28
01
2020
accepted:
05
02
2020
entrez:
13
2
2020
pubmed:
13
2
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Acute lymphoblastic leukemia (ALL) is an aggressive hematologic neoplastic disorder that arises from the clonal expansion of transformed T-cell or B-cell precursors. Thanks to progress in chemotherapy protocols, ALL outcome has significantly improved. However, drug-resistance remains an unresolved issue in the treatment of ALL and toxic effects limit dose escalation of current chemotherapeutics. Therefore, the identification of novel targeted therapies to support conventional chemotherapy is required. The Wnt/β-catenin pathway is a conserved signaling axis involved in several physiological processes such as development, differentiation, and adult tissue homeostasis. As a result, deregulation of this cascade is closely related to initiation and progression of various types of cancers, including hematological malignancies. In particular, deregulation of this signaling network is involved in the transformation of healthy HSCs in leukemic stem cells (LSCs), as well as cancer cell multi-drug-resistance. This review highlights the recent findings on the role of Wnt/β-catenin in hematopoietic malignancies and provides information on the current status of Wnt/β-catenin inhibitors with respect to their therapeutic potential in the treatment of ALL.
Identifiants
pubmed: 32046053
pii: ijms21031098
doi: 10.3390/ijms21031098
pmc: PMC7037748
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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