Evolving Cell-Based and Cell-Free Clinical Strategies for Treating Severe Human Liver Diseases.
cell therapy
extracellular vesicles
liver diseases
organ printing
organoids
scaffolds
transplantation
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
07 02 2020
07 02 2020
Historique:
received:
16
12
2019
revised:
21
01
2020
accepted:
06
02
2020
entrez:
13
2
2020
pubmed:
13
2
2020
medline:
13
2
2021
Statut:
epublish
Résumé
Liver diseases represent a major global health issue, and currently, liver transplantation is the only viable alternative to reduce mortality rates in patients with end-stage liver diseases. However, scarcity of donor organs and risk of recidivism requiring a re-transplantation remain major obstacles. Hence, much hope has turned towards cell-based therapy. Hepatocyte-like cells obtained from embryonic stem cells or adult stem cells bearing multipotent or pluripotent characteristics, as well as cell-based systems, such as organoids, bio-artificial liver devices, bioscaffolds and organ printing are indeed promising. New approaches based on extracellular vesicles are also being investigated as cell substitutes. Extracellular vesicles, through the transfer of bioactive molecules, can modulate liver regeneration and restore hepatic function. This review provides an update on the current state-of-art cell-based and cell-free strategies as alternatives to liver transplantation for patients with end-stage liver diseases.
Identifiants
pubmed: 32046114
pii: cells9020386
doi: 10.3390/cells9020386
pmc: PMC7072646
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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