Predictors of Postoperative Seizure Outcome in Low Grade Glioma: From Volumetric Analysis to Molecular Stratification.
ROC curves
extent of resection
low grade glioma
molecular markers
seizure outcome
tumor growth pattern
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
08 Feb 2020
08 Feb 2020
Historique:
received:
24
12
2019
revised:
21
01
2020
accepted:
06
02
2020
entrez:
13
2
2020
pubmed:
13
2
2020
medline:
13
2
2020
Statut:
epublish
Résumé
The importance of the extent of resection (EOR) has been widely demonstrated as the main predictor for survival, nevertheless its effect on tumor related epilepsy is less investigated. A total of 155 patients were enrolled after a first-line surgery for supratentorial Diffuse Low Grade Gliomas (DLGGs). Postoperative seizure outcome was analyzed stratifying the results by tumor volumetric data and molecular markers according to 2016 WHO classification. Receiver operating characteristic (ROC) curves were computed to asses EOR, residual tumor volume, and ΔT2T1 MRI index (expressing the tumor growing pattern) corresponding to optimal seizure outcome. A total of 70.97% of patients were seizure-free 18 months after surgery. Better seizure outcome was observed in IDH1/2 mutated and 1p/19q codeleted subgroup. At multivariate analysis, age (
Identifiants
pubmed: 32046310
pii: cancers12020397
doi: 10.3390/cancers12020397
pmc: PMC7072647
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Semin Oncol. 2003 Dec;30(6 Suppl 19):49-52
pubmed: 14765386
J Neurosurg. 2013 Jun;118(6):1157-68
pubmed: 23495881
Epilepsy Res. 2015 Jan;109:100-5
pubmed: 25524848
Brain. 2014 Feb;137(Pt 2):449-62
pubmed: 24374407
Acta Neuropathol. 2018 Nov;136(5):805-810
pubmed: 30259105
J Neurooncol. 2006 Jun;78(2):179-85
pubmed: 16739029
Sci Transl Med. 2014 Jul 9;6(244):244ra89
pubmed: 25009229
Epilepsia. 2010 Jun;51(6):1069-77
pubmed: 19889013
Neurology. 2017 May 9;88(19):1805-1813
pubmed: 28404805
Curr Opin Neurol. 2010 Dec;23(6):603-9
pubmed: 20733482
Clin Neuropathol. 2014 Jul-Aug;33(4):292-8
pubmed: 24986208
Epilepsy Behav. 2019 Feb;91:20-24
pubmed: 30420228
Epilepsy Behav. 2018 Jan;78:30-36
pubmed: 29172136
J Neurosurg. 2012 May;116(5):1042-8
pubmed: 22304450
Nat Rev Clin Oncol. 2018 Feb;15(2):112-125
pubmed: 29158591
J Neurosurg. 2012 Jun;116(6):1226-34
pubmed: 22404676
Neuro Oncol. 2012 Sep;14 Suppl 4:iv55-64
pubmed: 23095831
Curr Opin Oncol. 2010 Nov;22(6):611-20
pubmed: 20706121
Epilepsia. 2014 Sep;55(9):1438-43
pubmed: 24903073
Neurosurgery. 2008 Oct;63(4):700-7; author reply 707-8
pubmed: 18981880
Nat Rev Neurol. 2016 Apr;12(4):204-16
pubmed: 26965673
Neuro Oncol. 2015 Aug;17(8):1121-31
pubmed: 25921022
Neurosurg Rev. 2009 Jul;32(3):275-84; discussion 284-6
pubmed: 19205766
Electroencephalogr Clin Neurophysiol. 1993 Dec;87(6):437-58
pubmed: 7508377
Stereotact Funct Neurosurg. 1992;58(1-4):153-61
pubmed: 1439333
J Clin Oncol. 2008 Mar 10;26(8):1338-45
pubmed: 18323558
Neurol Sci. 2019 Oct;40(10):2217-2234
pubmed: 31392641
Epilepsia. 2017 Apr;58(4):522-530
pubmed: 28276060
J Clin Neurosci. 2016 Sep;31:56-62
pubmed: 27406953
Neurosurgery. 2019 Aug 1;85(2):E332-E340
pubmed: 30395304
J Neurosurg. 2016 Oct;125(4):877-887
pubmed: 26848912
J Neurosurg. 2012 Dec;117(6):1039-52
pubmed: 23039150
Seizure. 2012 Apr;21(3):153-9
pubmed: 22300623
J Neurosurg. 2018 Apr;128(4):1084-1090
pubmed: 28548599
J Digit Imaging. 2004 Sep;17(3):205-16
pubmed: 15534753
Epilepsy Res. 2001 Mar;43(3):179-91
pubmed: 11248530
Neurosurgery. 2012 May;70(5):1081-93; discussion 1093-4
pubmed: 22067417
J Cancer Res Clin Oncol. 2014 Jan;140(1):45-51
pubmed: 24149775
N Engl J Med. 2009 Feb 19;360(8):765-73
pubmed: 19228619
Brain Pathol. 2019 Jul;29(4):469-472
pubmed: 31038238
Acta Neuropathol. 2016 Jun;131(6):803-20
pubmed: 27157931
J Neurosurg. 2014 Jan;120(1):12-23
pubmed: 24236654
Clin Neuropathol. 2014 Jan-Feb;33(1):6-14
pubmed: 24359605
Neuroimage. 2011 Jun 1;56(3):992-1000
pubmed: 21414413