Interleukin 10: the critical role of a pleiotropic cytokine in food allergy.
Dedritic cells
Food allergy
IL-10
IL-10 gene polymorphisms
Tregs
Journal
Allergologia et immunopathologia
ISSN: 1578-1267
Titre abrégé: Allergol Immunopathol (Madr)
Pays: Singapore
ID NLM: 0370073
Informations de publication
Date de publication:
Historique:
received:
22
06
2019
revised:
08
10
2019
accepted:
17
10
2019
pubmed:
13
2
2020
medline:
20
4
2021
entrez:
13
2
2020
Statut:
ppublish
Résumé
Despite advances in research, the pathophysiology of food allergy has not yet been fully elucidated. IL-10 has both a pro- and anti-inflammatory effect on the development of food allergy and in order to understand its different immune-modulatory effects the factors that influence the inflammatory microenvironment need to be taken into account. Specific single nucleotide polymorphisms of the IL-10 gene seem to confer an increased risk of developing food allergy, but to date there is a substantial lack of genome- wide association studies regarding the genetic and epigenetic underpinnings of the disease. Special interest has been drawn to the development of allergen-specific regulatory CD4+CD25+ T-cells secreting IL-10 in the immunotherapy of allergic diseases. In addition, a distinct population of human tolerogenic dendritic cells (DC), DC-10 seems to hold great potential and could potentially serve as a therapeutic tool to improve the management of food allergy.
Identifiants
pubmed: 32046867
pii: S0301-0546(20)30002-1
doi: 10.1016/j.aller.2019.10.003
pii:
doi:
Substances chimiques
Interleukin-10
130068-27-8
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
401-408Informations de copyright
Copyright © 2020. Published by Elsevier España, S.L.U.