Pathologic Complete Response after Neoadjuvant Chemotherapy and Impact on Breast Cancer Recurrence and Survival: A Comprehensive Meta-analysis.
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 06 2020
15 06 2020
Historique:
received:
23
10
2019
revised:
16
12
2019
accepted:
04
02
2020
pubmed:
13
2
2020
medline:
7
1
2021
entrez:
13
2
2020
Statut:
ppublish
Résumé
While various studies have highlighted the prognostic significance of pathologic complete response (pCR) after neoadjuvant chemotherapy (NAT), the impact of additional adjuvant therapy after pCR is not known. PubMed was searched for studies with NAT for breast cancer and individual patient-level data was extracted for analysis using plot digitizer software. HRs, with 95% probability intervals (PI), measuring the association between pCR and overall survival (OS) or event-free survival (EFS), were estimated using Bayesian piece-wise exponential proportional hazards hierarchical models including pCR as predictor. Overall, 52 of 3,209 publications met inclusion criteria, totaling 27,895 patients. Patients with a pCR after NAT had significantly better EFS (HR = 0.31; 95% PI, 0.24-0.39), particularly for triple-negative (HR = 0.18; 95% PI, 0.10-0.31) and HER2 Achieving pCR following NAT is associated with significantly better EFS and OS, particularly for triple-negative and HER2
Identifiants
pubmed: 32046998
pii: 1078-0432.CCR-19-3492
doi: 10.1158/1078-0432.CCR-19-3492
pmc: PMC7299787
mid: NIHMS1560154
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
2838-2848Subventions
Organisme : NCI NIH HHS
ID : K12 CA087723
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001100
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentOn
Informations de copyright
©2020 American Association for Cancer Research.
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