Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganese.
MESM
calcimycin
calcium transport
ionomycin
ionophore
manganese
metal homeostasis
neurobiology
neurodegenerative disease
transport metal
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
20 03 2020
20 03 2020
Historique:
received:
10
07
2019
revised:
11
02
2020
pubmed:
13
2
2020
medline:
15
12
2020
entrez:
13
2
2020
Statut:
ppublish
Résumé
Available assays for measuring cellular manganese (Mn) levels require cell lysis, restricting longitudinal experiments and multiplexed outcome measures. Conducting a screen of small molecules known to alter cellular Mn levels, we report here that one of these chemicals induces rapid Mn efflux. We describe this activity and the development and implementation of an assay centered on this small molecule, named
Identifiants
pubmed: 32047113
pii: S0021-9258(17)48780-1
doi: 10.1074/jbc.RA119.009781
pmc: PMC7086026
doi:
Substances chimiques
Ionophores
0
Calcimycin
37H9VM9WZL
Manganese
42Z2K6ZL8P
Ionomycin
56092-81-0
Calcium
SY7Q814VUP
Fura-2
TSN3DL106G
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3875-3890Subventions
Organisme : NLM NIH HHS
ID : T15 LM007450
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007028
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES016931
Pays : United States
Organisme : NIH HHS
ID : S10 OD025281
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES010563
Pays : United States
Organisme : NIH HHS
ID : S10 OD021734
Pays : United States
Informations de copyright
© 2020 Horning et al.
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