Effects of a solid lipid curcumin particle formulation on chronic activation of microglia and astroglia in the GFAP-IL6 mouse model.

Animals Anti-Inflammatory Agents / pharmacology Astrocytes / drug effects Cerebellum / cytology Curcumin / analogs & derivatives Dendrites / drug effects Female Glial Fibrillary Acidic Protein / genetics Hippocampus / cytology Interleukin-6 / genetics Male Mice Mice, Inbred C57BL Microglia / drug effects Movement Neurodegenerative Diseases / drug therapy Neuroprotective Agents / pharmacology

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
11 02 2020
Historique:
received: 13 09 2019
accepted: 17 01 2020
entrez: 13 2 2020
pubmed: 13 2 2020
medline: 11 11 2020
Statut: epublish

Résumé

Chronic glial activation is characterized by increased numbers of activated glial cells, secreting free radicals and cytotoxic cytokines, subsequently causing neuronal damage. In order to investigate the anti-inflammatory activity of Longvida

Identifiants

DOI: 10.1038/s41598-020-58838-2 PMID: 32047191 PMC: PMC7012877
pubmed: 32047191
doi: 10.1038/s41598-020-58838-2
pii: 10.1038/s41598-020-58838-2
pmc: PMC7012877
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Glial Fibrillary Acidic Protein 0
Interleukin-6 0
Neuroprotective Agents 0
Curcumin IT942ZTH98

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2365

Références

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Auteurs

Faheem Ullah (F)

Department of Pharmacology, School of Medicine, Western Sydney University, Locked Bag 1797, Penrith, New South Wales, 2751, Australia.

Rustam Asgarov (R)

Department of Pharmacology, School of Medicine, Western Sydney University, Locked Bag 1797, Penrith, New South Wales, 2751, Australia.

Madhuri Venigalla (M)

Department of Pharmacology, School of Medicine, Western Sydney University, Locked Bag 1797, Penrith, New South Wales, 2751, Australia.

Huazheng Liang (H)

Department of Pharmacology, School of Medicine, Western Sydney University, Locked Bag 1797, Penrith, New South Wales, 2751, Australia.
Department of Neurology, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.
ORCID: 0000-0001-9097-7357

Garry Niedermayer (G)

School of Science and Health, Western Sydney University, Locked Bag 1797, Penrith, New South Wales, 2751, Australia.

Gerald Münch (G)

Department of Pharmacology, School of Medicine, Western Sydney University, Locked Bag 1797, Penrith, New South Wales, 2751, Australia.
NICM Health Research Institute, Western Sydney University, Locked Bag 1797, Penrith, New South Wales, 2751, Australia.
ORCID: 0000-0002-4873-7779

Erika Gyengesi (E)

Department of Pharmacology, School of Medicine, Western Sydney University, Locked Bag 1797, Penrith, New South Wales, 2751, Australia. e.gyengesi@westernsydney.edu.au.
NICM Health Research Institute, Western Sydney University, Locked Bag 1797, Penrith, New South Wales, 2751, Australia. e.gyengesi@westernsydney.edu.au.
ORCID: 0000-0001-7371-7385

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Rhombencéphale › Métencéphale › Cervelet › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Cellules › Neurones › Dendrites › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines de filaments intermédiaires › Protéine gliofibrillaire acide › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Effects of a solid lipid curcumin particle...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Effects of a solid lipid curcumin particle...