The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 02 2020
11 02 2020
Historique:
received:
28
10
2019
accepted:
20
01
2020
entrez:
13
2
2020
pubmed:
13
2
2020
medline:
11
11
2020
Statut:
epublish
Résumé
Visceral white adipose tissue (vWAT) expands and undergoes extensive remodeling during diet-induced obesity. Much is known about the contribution of various stromal vascular cells to the remodeling process, but less is known of the changes that occur within the adipocyte as it becomes progressively dysfunctional. Here, we performed a transcriptome analysis of isolated vWAT adipocytes to assess global pathway changes occurring in response to a chronic high fat diet (HFD). The data demonstrate that the adipocyte responds to the HFD by adopting a fibroblast-like phenotype, characterized by enhanced expression of ECM, focal adhesion and cytoskeletal genes and suppression of many adipocyte programs most notably those associated with mitochondria. This study reveals that during obesity the adipocyte progressively becomes metabolically dysfunctional due to its acquisition of fibrogenic functions. We propose that mechano-responsive transcription factors such as MRTFA and SRF contribute to both upregulation of morphological genes as well as suppression of mitochondrial programs.
Identifiants
pubmed: 32047213
doi: 10.1038/s41598-020-59284-w
pii: 10.1038/s41598-020-59284-w
pmc: PMC7012923
doi:
Substances chimiques
Extracellular Matrix Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2380Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK117161
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM127625
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100422
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK046200
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117163
Pays : United States
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