Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 02 2020
11 02 2020
Historique:
received:
01
08
2019
accepted:
22
01
2020
entrez:
13
2
2020
pubmed:
13
2
2020
medline:
11
11
2020
Statut:
epublish
Résumé
Immunopathogenesis in systemic viral infections can induce a septic state with leaky capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment options. Murine gammaherpesvirus-68 (MHV-68) intraperitoneal infection is a gammaherpesvirus model for producing severe vasculitis, colitis and lethal hemorrhagic pneumonia in interferon gamma receptor-deficient (IFNγR
Identifiants
pubmed: 32047224
doi: 10.1038/s41598-020-59269-9
pii: 10.1038/s41598-020-59269-9
pmc: PMC7012916
doi:
Substances chimiques
Anti-Bacterial Agents
0
Peptide Fragments
0
Recombinant Proteins
0
Serpins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2371Subventions
Organisme : NIAID NIH HHS
ID : R01 AI100987
Pays : United States
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