The miR-34 family and its clinical significance in ovarian cancer.

carcinogenesis miR-34 ovarian cancer p53 survival

Journal

Journal of Cancer
ISSN: 1837-9664
Titre abrégé: J Cancer
Pays: Australia
ID NLM: 101535920

Informations de publication

Date de publication:
2020
Historique:
received: 04 02 2019
accepted: 20 11 2019
entrez: 13 2 2020
pubmed: 13 2 2020
medline: 13 2 2020
Statut: epublish

Résumé

The tumor suppressor miR-34 family is transcriptionally induced by p53. Clinical significance of the various miR-34 family members has not been studied in ovarian cancer. In 228 ovarian cancers and in 19 non-neoplastic fallopian tube samples we analysed miR-34 a/b/c expression in relation to clinicopathological characteristics and clinical outcome. We found significantly lower levels of miR-34 a/b/c in ovarian cancers as compared to control-tissues (

Identifiants

pubmed: 32047551
doi: 10.7150/jca.33831
pii: jcav11p1446
pmc: PMC6995379
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1446-1456

Informations de copyright

© The author(s).

Déclaration de conflit d'intérêts

Competing Interests: The authors have declared that no competing interest exists.

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Auteurs

Hannah Welponer (H)

Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Tyrol, 6020, Austria.

Irina Tsibulak (I)

Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Tyrol, 6020, Austria.

Verena Wieser (V)

Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Tyrol, 6020, Austria.

Christine Degasper (C)

Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Tyrol, 6020, Austria.

Giridhar Shivalingaiah (G)

Division of Human Genetics, Medical University of Innsbruck, Innsbruck, Tyrol, 6020, Austria.

Sören Wenzel (S)

Division of Human Genetics, Medical University of Innsbruck, Innsbruck, Tyrol, 6020, Austria.

Susanne Sprung (S)

Institute of Pathology, Medical University of Innsbruck, Innsbruck, Tyrol, 6020, Austria.

Christian Marth (C)

Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Tyrol, 6020, Austria.

Hubert Hackl (H)

Biocenter, Division of Bioinformatics, Medical University of Innsbruck, Innsbruck, Tyrol, 6020, Austria.

Heidelinde Fiegl (H)

Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Tyrol, 6020, Austria.

Alain G Zeimet (AG)

Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Tyrol, 6020, Austria.

Classifications MeSH