Case Report: Cetuximab use in advanced cutaneous squamous cell carcinoma resistant to chemotherapy.
EGFR
cetuximab
cutaneous squamous cell carcinoma
non-melanoma skin cancer
Journal
F1000Research
ISSN: 2046-1402
Titre abrégé: F1000Res
Pays: England
ID NLM: 101594320
Informations de publication
Date de publication:
2019
2019
Historique:
accepted:
06
06
2019
entrez:
13
2
2020
pubmed:
13
2
2020
medline:
4
6
2020
Statut:
epublish
Résumé
We present the case of a 60-year-old man with unresectable cutaneous squamous cell carcinoma (cSCC) of the sternal area, which was not amenable to radiation therapy. The treatment history of this patient is remarkable as the disease had progressed through all lines of conventional therapy established in the literature. We decided to initiate treatment with epidermal growth factor receptor (EGFR) inhibitor cetuximab and we reassessed the patient after 12 weeks with a whole-body CT scan, documenting stability in the size and radiologic features of the disease. Cetuximab, like all current treatments for advanced cSCC, is administered off-label and proved effective in preventing further progression of disease in our patient.
Identifiants
pubmed: 32047600
doi: 10.12688/f1000research.19149.2
pmc: PMC6993817
doi:
Substances chimiques
Antineoplastic Agents, Immunological
0
Cetuximab
PQX0D8J21J
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
933Informations de copyright
Copyright: © 2019 Sernicola A et al.
Déclaration de conflit d'intérêts
No competing interests were disclosed.
Références
J Dtsch Dermatol Ges. 2008 Dec;6(12):1066-9
pubmed: 19138272
JAMA Dermatol. 2014 Sep;150(9):970-3
pubmed: 24740281
Eur J Cancer. 2015 Sep;51(14):1989-2007
pubmed: 26219687
Eur J Dermatol. 2018 Feb 1;28(1):78-81
pubmed: 29336323
Oncology. 2009;77(2):120-3
pubmed: 19622902
J Am Acad Dermatol. 2018 Feb;78(2):249-261
pubmed: 29332705
Head Neck. 2015 Aug;37(8):1088-95
pubmed: 24710745
J Clin Med. 2018 Jan 10;7(1):
pubmed: 29320468
J Clin Oncol. 2011 Sep 1;29(25):3419-26
pubmed: 21810686
N Engl J Med. 2018 Jul 26;379(4):341-351
pubmed: 29863979