The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea.
dermatology
mast cell
pathophysiology
rosacea
treatment
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
10
2019
accepted:
18
12
2019
entrez:
13
2
2020
pubmed:
13
2
2020
medline:
13
2
2020
Statut:
epublish
Résumé
Rosacea is a chronic inflammatory cutaneous disorder that adversely affects patient's health and quality of life due to the complex course and the need for repeated treatment. The exact molecular mechanisms of rosacea are unclear. Mast cells are innate immune cells that can be found in virtually all tissues. Recently, increasing evidence has indicated that mast cells have important effects on the pathogenesis of rosacea. In this review article, we describe recent advances of skin mast cells in the development of rosacea. These studies suggested that mast cells can be an important immune cell that connected innate immunity, nerves, and blood vessels in the development of rosacea. Moreover, we review the inhibition of mast cells for the potential treatment of rosacea.
Identifiants
pubmed: 32047752
doi: 10.3389/fmed.2019.00324
pmc: PMC6997331
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
324Informations de copyright
Copyright © 2020 Wang, Wang, Hao, Wen, Du, He and Jiang.
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