Pathogens causing diarrhoea among Bangladeshi children with malignancy: Results from two pilot studies.
Bangladesh
Cancer
Child
Cryptosporidium
Gastroenteritis
Parasite
Journal
World journal of clinical cases
ISSN: 2307-8960
Titre abrégé: World J Clin Cases
Pays: United States
ID NLM: 101618806
Informations de publication
Date de publication:
26 Jan 2020
26 Jan 2020
Historique:
received:
28
08
2019
revised:
27
11
2019
accepted:
13
12
2019
entrez:
13
2
2020
pubmed:
13
2
2020
medline:
13
2
2020
Statut:
ppublish
Résumé
Diarrhoea is a frequent symptom in children with cancer, and occurs due to a composite effect of underlying disease and immunosuppression consequent to therapy, malnutrition, and non-infective aetiologies such as mucositis. In a large proportion of cases, the aetiology of diarrhoea remains unknown but is often attributed to multiple pathogens including parasites. To identify and describe the pathogens causing diarrhoea in Bangladeshi children with cancer. Two cross-sectional pilot studies were conducted involving paediatric oncology patients with diarrhoea. Stool samples were collected from children who were hospitalised with or without being treated with chemotherapy during the study period, and had diarrhoea at any stage during their admission. In the first study, stool samples were tested by conventional microbiological methods and by polymerase chain reaction for parasites, and by immunoassays for In the first study These pilot data suggest that parasites are important aetiologies of diarrhoea in Bangladeshi children with malignancy. While molecular diagnostic tools detect an array of stool pathogens with greater sensitivity, conventional diagnostic methods are also useful.
Sections du résumé
BACKGROUND
BACKGROUND
Diarrhoea is a frequent symptom in children with cancer, and occurs due to a composite effect of underlying disease and immunosuppression consequent to therapy, malnutrition, and non-infective aetiologies such as mucositis. In a large proportion of cases, the aetiology of diarrhoea remains unknown but is often attributed to multiple pathogens including parasites.
AIM
OBJECTIVE
To identify and describe the pathogens causing diarrhoea in Bangladeshi children with cancer.
METHODS
METHODS
Two cross-sectional pilot studies were conducted involving paediatric oncology patients with diarrhoea. Stool samples were collected from children who were hospitalised with or without being treated with chemotherapy during the study period, and had diarrhoea at any stage during their admission. In the first study, stool samples were tested by conventional microbiological methods and by polymerase chain reaction for parasites, and by immunoassays for
RESULTS
RESULTS
In the first study
CONCLUSION
CONCLUSIONS
These pilot data suggest that parasites are important aetiologies of diarrhoea in Bangladeshi children with malignancy. While molecular diagnostic tools detect an array of stool pathogens with greater sensitivity, conventional diagnostic methods are also useful.
Identifiants
pubmed: 32047775
doi: 10.12998/wjcc.v8.i2.276
pmc: PMC7000943
doi:
Types de publication
Journal Article
Langues
eng
Pagination
276-283Informations de copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: There are no conflicts of interest to disclose in relation to this manuscript.
Références
J Pediatr Gastroenterol Nutr. 2010 Jul;51(1):2-7
pubmed: 20512057
Parasitol Res. 2017 Sep;116(9):2507-2515
pubmed: 28730516
Gut. 1994 Nov;35(11):1608-12
pubmed: 7828982
Pediatr Infect Dis J. 1997 Dec;16(12):1131-4
pubmed: 9427457
J Trop Pediatr. 1999 Aug;45(4):241-2
pubmed: 10467838
Asian Pac J Cancer Prev. 2019 Feb 26;20(2):495-501
pubmed: 30803212
PLoS Negl Trop Dis. 2016 May 04;10(5):e0004564
pubmed: 27144404
Am J Trop Med Hyg. 2007 Apr;76(4):713-7
pubmed: 17426176
Pediatr Blood Cancer. 2019 May;66(5):e27604
pubmed: 30666782
Nat Clin Pract Gastroenterol Hepatol. 2008 Dec;5(12):682-96
pubmed: 18941434
J Clin Microbiol. 1999 Nov;37(11):3458-64
pubmed: 10523534
Clin Infect Dis. 2012 Jan 15;54(2):185-92
pubmed: 22109945
Infect Genet Evol. 2017 Nov;55:127-130
pubmed: 28867592
J Diarrhoeal Dis Res. 1996 Sep;14(3):211-3
pubmed: 9019017
Iran J Pediatr. 2013 Aug;23(4):473-6
pubmed: 24427503
Clin Microbiol Rev. 2002 Jan;15(1):145-54
pubmed: 11781272
Pediatr Blood Cancer. 2004 Apr;42(4):338-42
pubmed: 14966830
J Paediatr Child Health. 1999 Jun;35(3):300-2
pubmed: 10404455
J Clin Microbiol. 2010 Nov;48(11):4140-6
pubmed: 20861334
Clin Infect Dis. 2009 May 1;48(9):1191-7
pubmed: 19323634
J Hosp Infect. 2017 Jan;95(1):123-125
pubmed: 27825673
Turk J Pediatr. 2003 Apr-Jun;45(2):129-32
pubmed: 12921299
Rev Alerg Mex. 1999 Jan-Feb;46(1):26-9
pubmed: 10232025