MICA-129 Met/Val polymorphism could be a genetic biomarker for Familial Breast Cancer in the Tunisian population.
Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Biomarkers, Tumor
/ genetics
Breast Neoplasms
/ genetics
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Histocompatibility Antigens Class I
/ genetics
Humans
Middle Aged
Polymorphism, Single Nucleotide
/ genetics
Tunisia
/ epidemiology
Young Adult
MICA
Tunisian population
early-onset breast cancer
familial breast cancer
polymorphism
Journal
International journal of immunogenetics
ISSN: 1744-313X
Titre abrégé: Int J Immunogenet
Pays: England
ID NLM: 101232337
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
27
11
2019
revised:
05
01
2020
accepted:
20
01
2020
pubmed:
13
2
2020
medline:
10
6
2021
entrez:
13
2
2020
Statut:
ppublish
Résumé
Identification of candidate genes associated with susceptibility of breast cancer can have a significant impact at a cancer management national healthcare systems level, making genetic testing more affordable and cost-effective. We have previously shown that the major histocompatibility complex class I-related chain A (MICA) was related to breast cancer and plays an important role in modulating immune response mechanisms through NKG2D receptor activation. Compared to our previous study, in this work, we recruited a new cohort composed of 354 unrelated Tunisian women affected by breast cancer and 380 age-matched women as controls, all genotyped for MICA-129 Met/Val (rs 1051792). Subsequently, we exanimated the distribution of this polymorphism in ten families. As a result, an association was found between the Val allele and Val/Val genotype and the risk of breast cancer (p = 2.5 × 10
Substances chimiques
Biomarkers, Tumor
0
Histocompatibility Antigens Class I
0
MHC class I-related chain A
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
406-413Informations de copyright
© 2020 John Wiley & Sons Ltd.
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