Percutaneous intrarenal transplantation of differentiated induced pluripotent stem cells into newborn mice.
newborn mouse
pluripotent stem cells
podocytes
transplantation
Journal
Anatomical record (Hoboken, N.J. : 2007)
ISSN: 1932-8494
Titre abrégé: Anat Rec (Hoboken)
Pays: United States
ID NLM: 101292775
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
06
08
2019
revised:
22
11
2019
accepted:
07
12
2019
pubmed:
13
2
2020
medline:
10
4
2021
entrez:
13
2
2020
Statut:
ppublish
Résumé
The in vivo engraftment of induced pluripotent stem cell (iPSC)-derived podocytes following allogeneic transplantation into host kidneys remains a challenge. Here we investigate the survival and engraftment of human dermal fibroblasts-derived differentiated iPSCs using a newborn mouse model, which represents a receptive immunoprivileged host environment. iPSCs were generated from skin biopsies of patients using Sendai virus reprogramming. Differentiation of nephrin (NPHS1)-green fluorescent protein (GFP) iPSCs into kidney podocytes (iPSC-PODs) was performed by the addition of Activin A, bone morphogenetic protein 7 (BMP7), and retinoic acid over 10 days of culture. To assess the in vivo incorporation of cells, undifferentiated iPSCs or day 10 iPSC-PODs, were labeled with either carboxyfluorescein succinimidyl ester (CFSE) or Qdot nanocrystals (Q705). Thereafter, 1 × 10
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2603-2612Informations de copyright
© 2020 American Association for Anatomy.
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