Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.
Aldehyde Dehydrogenase, Mitochondrial
/ genetics
Animals
Gene Expression Regulation
Genotype
High-Temperature Requirement A Serine Peptidase 2
/ genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria
/ metabolism
Muscle, Skeletal
/ metabolism
Oxygen Consumption
Reactive Oxygen Species
/ metabolism
acetaldehyde dehydrogenase 2
mitochondria
skeletal muscle
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
pubmed:
13
2
2020
medline:
28
7
2020
entrez:
13
2
2020
Statut:
ppublish
Résumé
Acetaldehyde dehydrogenase 2 (ALDH2) is an enzyme involved in redox homeostasis as well as the detoxification process in alcohol metabolism. Nearly 8% of the world's population have an inactivating mutation in the
Identifiants
pubmed: 32048867
doi: 10.1152/ajpregu.00089.2019
doi:
Substances chimiques
Reactive Oxygen Species
0
ALDH2 protein, mouse
EC 1.2.1.3
Aldehyde Dehydrogenase, Mitochondrial
EC 1.2.1.3
High-Temperature Requirement A Serine Peptidase 2
EC 3.4.21.108
Htra2 protein, mouse
EC 3.4.21.108
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM