NAD
SIRT2
aging
embryo development
female fertility
in vitro fertilization
infertility
nicotinamide adenine dinucleotide (NAD+)
nicotinamide mononucleotide (NMN)
oocyte
reproductive aging
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
11 02 2020
11 02 2020
Historique:
received:
12
09
2019
revised:
03
11
2019
accepted:
17
01
2020
entrez:
13
2
2020
pubmed:
13
2
2020
medline:
9
3
2021
Statut:
ppublish
Résumé
Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of oocyte quality with age accompanies declining levels of the prominent metabolic cofactor nicotinamide adenine dinucleotide (NAD
Identifiants
pubmed: 32049001
pii: S2211-1247(20)30083-8
doi: 10.1016/j.celrep.2020.01.058
pmc: PMC7063679
mid: NIHMS1560015
pii:
doi:
Substances chimiques
NAD
0U46U6E8UK
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1670-1681.e7Subventions
Organisme : NIA NIH HHS
ID : DP1 AG058605
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG019719
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100263
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG028730
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests L.E.W., H.A.H., and D.A.S. are cofounders, shareholders, directors, and advisers of Jumpstart Fertility Inc., which was founded to develop the work described here, and are inventors on a patent (WO2019023748A1 “Methods to improve fertility”) that forms the basis of this work and has been licensed to Jumpstart Fertility. D.A.S. is an inventor on a patent (WO2013002880A1) that was previously licensed to Jumpstart Fertility. The salaries of M.J.B. and D.M.G. working in the labs of L.E.W. and R.B.G. at UNSW were paid by sponsored research from Jumpstart Fertility to UNSW. K.S. was an employee of Jumpstart Fertility. W.-H.J.H. and D.R.L. hold shares in Jumpstart Fertility. H.A.H. undertakes ART in the private sector in affiliation with Queensland Fertility Group. L.E.W. and D.A.S. are also advisers and shareholders in EdenRoc Sciences (Metro Biotech NSW, Metro Biotech, Liberty Biosecurity) and in Life Biosciences LLC and its daughter companies (Jumpstart Fertility, Continuum Biosciences, Senolytic Therapeutics, Selphagy, Animal Biosciences, Iduna). L.E.W. provides consulting work for Life Biosciences and is an adviser and shareholder in Intravital Pty Ltd. D.A.S. is also a founder, equity owner, adviser, director, consultant, investor, and/or inventor on patents licensed to Vium, Jupiter Orphan Therapeutics, Cohbar, Galilei Biosciences, Wellomics, EdenRoc Sciences (and affiliates Arc-Bio, Dovetail Genomics, Claret, Revere Biosciences, UpRNA, MetroBiotech, Liberty Biosecurity), Life Biosciences (and affiliates Selphagy, Senolytic Therapeutics, Spotlight Therapeutics, Animal Biosciences, Iduna, Continuum, Jumpstart Fertility, Iduna). D.A.S. is an inventor on a patent application filed by Mayo Clinic and Harvard Medical School that has been licensed to Elysium Health. For details see https://genetics.med.harvard.edu/sinclair.
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