Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects.

Apoptosis Apoptosis Regulatory Proteins Humans Intracellular Signaling Peptides and Proteins Pancreatic Neoplasms Reactive Oxygen Species

Journal

Cancer cell
ISSN: 1878-3686
Titre abrégé: Cancer Cell
Pays: United States
ID NLM: 101130617

Informations de publication

Date de publication:
10 02 2020
Historique:
entrez: 13 2 2020
pubmed: 13 2 2020
medline: 17 7 2020
Statut: ppublish

Résumé

The role of ROS in cancer is complex, with studies demonstrating both pro- and anti-tumor effects. In a pancreatic ductal adenocarcinoma model, ROS limitation through TIGAR has been shown to initially support cancer development but to later become a metabolic liability in metastasizing cells that is counteracted by decreased TIGAR expression.

Identifiants

DOI: 10.1016/j.ccell.2020.01.009 PMID: 32049042
pubmed: 32049042
pii: S1535-6108(20)30048-9
doi: 10.1016/j.ccell.2020.01.009
pii:
doi:

Substances chimiques

Apoptosis Regulatory Proteins 0
Intracellular Signaling Peptides and Proteins 0
Reactive Oxygen Species 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

141-142

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests S.-M.F. has received funding from Bayer, Merck, and BlackBelt Therapeutics.

Auteurs

Sarah-Maria Fendt (SM)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.

Sophia Y Lunt (SY)

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, USA. Electronic address: sophia@msu.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Dynamic ROS Regulation by TIGAR: Balancing...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Dynamic ROS Regulation by TIGAR: Balancing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dynamic ROS Regulation by TIGAR: Balancing...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Dynamic ROS Regulation by TIGAR: Balancing...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Dynamic ROS Regulation by TIGAR: Balancing...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Dynamic ROS Regulation by TIGAR: Balancing...